Available Technologies

Hair-Loss Treatment with Hair-Loss Gene Promotes New Hair Growth, Regulates Male-Pattern Baldness and Graying Hair

2419 — This hair-loss gene technology represents a non-surgical hair-loss treatment and a potential drug target for preventing further hair loss. The discovery of the APCDD1 gene, which causes hair loss, has potential for future male-pattern baldness treatments, and for regulating male and female hair growth, density of hair, and hair graying.  Hair loss affects millions of people worldwide. Hair loss can be an emotionally devastating skin disease, as measured by impact on quality of life. Two...

High-Resolution Visualization of Active Chromatin using an H2B-Enhanced GFP Fusion Reporter

2983 — Fluorescent reporter proteins such as GFP are widely used for imaging of live or fixed cells. Volumetric visualization of cells and the visual tracking of cell movement or division requires the use of easily identifiable tags that are visible at sub-cellular resolution in order to distinguish individual cells in a tagged population. One way this can be achieved is by targeting proteins expressed on conspicuous internal cell structures such as the nucleus for fluorescent labeling. Because...

Transgenic Mouse Strain for Visualization of Epithelial Cells during Renal Development

2986 — Although many of the genes involved in renal branching morphogenesis have been identified, little is known about the cellular behaviors that are actually controlled by these genes. Transgenic visualization techniques have been developed that are useful for studying renal morphogenesis at the tissue level; however, there is a need for techniques that can be used to study the behavior and shapes of individual cells during development. The technology is a transgenic mouse strain for ...

Form 1 Axin Knockin Mouse for Studying Functional Equivalence of Axin and Axin2

2988 — Axin is a ubiquitously expressed negative regulator that plays a significant role in the Wnt signaling pathway. Axin2 is a similar protein that shares several domains and binding sites with Axin, but is expressed in tissue- and developmental-stage-specific patterns and does not appear to be fully redundant with Axin in vivo in light of its inability to compensate for the total absence of Axin during embryonic development. Given that both Axin and Axin2 mutations have been observed in a n...

Tetracycline-Controlled System for Targeted Gene Expression in Axin2-Expressing Cells

2987 — The homologous proteins Axin and Axin2 are negative regulators of the Wnt signaling pathway. While the former is ubiquitously expressed, the latter is only expressed in specific tissue regions during embryogenesis. Although Axin and Axin2 exhibit apparent functional redundancy when the former is inserted into the locus of the latter, it is unclear to what extent their functions during early neural development overlap. The technology is a transgenic system for targeted gene express...

Axin and Axin2 Studied in Mutant Mouse for Functional Equivalence

2989 — Axin is a ubiquitously expressed negative regulator that plays a significant role in the Wnt signaling pathway. Axin2 is a similar protein that shares several domains and binding sites with Axin, but is expressed in tissue- and developmental-stage-specific patterns and does not appear to be fully redundant with Axin in vivo in light of its inability to compensate for the total absence of Axin during embryonic development. Given that both Axin and Axin2 mutations have been observed in a n...

Transgenic Mouse for Studying Embryogenetic Significance of RGS Domain on Axin

2991 — The Wnt signaling pathway plays an important role in embryogenesis. Axin is a negative regulator with a number of domains that interact with several proteins, some of which are known to be involved in Wnt signaling. Although loss of Axin is known to result in embryonic lethality, the functional significance of many of the protein-binding domains of Axin remains unclear. The technology is a mutant mouse with a modified Axin gene in which the APC-binding RGS domain has been deleted....

Mouse Model, Ret-S697A for Enteric Nervous System Function and Development Investigation

2993 — In biomedical research, transgenic mouse models are used to provide a test subject as a substitute for humans. These mouse models are made by altering a gene of interest in a mouse’s genome to induce or repress genetic expression. Although valuable, these mouse models need to be extensively investigated to validate that the desired model genotype was produced and the desired phenotype is being expressed. Understanding development and cell lineage are key to combating genetic and devel...

Ret-Men2B Mouse Model for Investigation of Pheochromocytoma Linked Endocrine Tumors

2994 — In biomedical research, transgenic mouse models are used to provide a test subject as a substitute for humans. These mouse models are made by altering a gene of interest in a mouse’s genome to induce or repress genetic expression. Although valuable, these mouse models need to be extensively investigated to validate that the desired model genotype was produced and the desired phenotype is being expressed. Understanding development and cell lineage are key to combating genetic and devel...

Mutant Mouse with Modified Axin Gene for Studying Embryogenetic Significance of Protein-Binding Domains

2995 — The Wnt signaling pathway plays an important role in embryogenesis. Axin is a negative regulator with a number of domains that interact with several proteins, some of which are known to be involved in Wnt signaling. Although loss of Axin is known to result in embryonic lethality, the functional significance of many of the protein-binding domains of Axin remains unclear. The technology is a mutant mouse with a modified Axin gene in which the 6 C-terminal amino acids (KVEKVD) have b...

Mouse Model as a Tool for Spatiotemporal and Lineage-Specific Gene Expression

2998 — In biomedical research, transgenic mouse models are utilized to provide a test subject as a substitute of human test subjects. These mouse models are designed by altering a gene of interest in a mouse’s genome to induce or repress genetic expression. This technology has been around since the 1980s, with many significant lines of transgenic and knockout mice being developed every year. However, these mouse models need to be extensively investigated to validate that the desired modeled gen...

VPS26aTg (Hbeta58) Cos Mouse Model for the Investigation of Alzheimer's Disease

2997 — In biomedical research, transgenic mouse models are used to provide a test subject as a substitute for human test subjects. These mouse models are designed by altering a gene of interest in the genome to induce or repress genetic expression. This technology has been around since the 1980s, with many significant lines of transgenic mice being developed every year. However, these mouse models need to be extensively investigated to validate that the desired genotype and phenotype is being e...

Mouse Model for Investigation of the Function of the Potentially Cancer Causing Ret Proto-Oncogene

2996 — In biomedical research, transgenic mouse models are utilized to provide a test subject as a substitute of human test subjects. These mouse models are designed by altering a gene of interest in a mouse’s genome to induce or repress genetic expression. This technology has been around since the 1980s, with many significant lines of transgenic and knockout mice being developed every year. However, these mouse models need to be extensively investigated to validate that the desired modeled gen...

Cell Lines for Packaging Retroviral Genomes for Transfer into Mouse Cells

139 — “Name of the Inventor: Arthur Bank Preparing Retroviral Genomes for Transfer into Mouse Cells The genes of the Moloney murine leukemia virus have been separated onto two plasmids - one containing the gag and pol genes, and the other containing either an amphotropic or an ecotropic env gene. Plasmids Transfected into NIH3T3 Cells to Create Two Retroviral Packaging Lines ...

Hair Growth Inhibited with Nucleic Acid Target Gene Interference

1084 — Hair removal products and methods for both cosmetic and therapeutic applications range from the old stand-by shaving to new treatments, such as laser procedures, electrolysis and a topical hair growth inhibitor Vaniqa. However, few products provide safe, easy, fast and painless long-term hair removal. As a result, the demand remains strong for new product innovations that promise more effective and efficient hair removal or hair growth elimination with a long-lasting effect, while elimin...

Cellular response regulation to DNA damage

1637 — Rad9 was previously identified by Dr. Lieberman ( ) and promotes cell survival through the regulation of DNA repair and the activation of cell cycle checkpoints induced by DNA damage. Mouse embryonic stem (ES) cells with a targeted deletion of Mrad9, the mouse ortholog of the gene, were created to evaluate the function of the protein in mammals. Mrad9-/- ES cells and Mrad9+/- mice are both available for use in cancer research. Both the mouse and cell lines, with deficient responses to DN...

MRI brain imaging for drug screening and disease detection

1714 — “Lead Inventor: Brain imaging MRI tt detect disease and test new drugs: MRI estimations of regional CBV have proven successful in mapping brain dysfunction. The ability to visualize the living brain with imaging techniques holds great promise in detecting the disease state and mapping time course of the disease. Imaging is potentially useful to screen new drugs and test drug efficacy. Traditional approaches typically require intravenous (IV) injections of contrast agents, which have a nu...

Transgenic mouse for cytokine expression and use as a stomach cancer model

1751 — Gastric cancer is one of most common cancers in the world. Currently there is a major gap in preclinical testing of cancer drugs/chemotherapy, as most cancer models have not been physiologic and have not mimicked human cancers. For example, xenograft model, the widely used method of studying cancer cell lines in immunodeficent mice is recognized to be of limited utility in terms of predicting efficacy of therapeutics. The technology provides a model of cancer in the mouse where the ca...

Mutant Mouse Cell Line for Studying Prostate Carcinogenesis

2305 — Prostate cancer is the most common cancer in men after skin cancer. Thus there is a need to study prostate carcinogenesis and possible cancer treatments. Nkx3.1 is involved cancer initiation, making it a useful marker for the detection and characterization of carcinomas. Nkx3.1; Pten compound mutant mice and cells derived from these mice are useful for investigating prostate carcinogenesis. This technology provides a mouse cell line derived from the Nkx3.1; Pten compound mutant mice. ...

Asynchronous Architecture: Alternative to Centralized Timing Control in Digital Systems

m09-002 — Nearly every current digital system utilizes a synchronous architecture where a global clock provides for centralized timing control. This type of design strategy “"synchronizes”“ all of the individual components, thereby forcing them to operate at the same fixed rate. However, as high performance digital systems continue to evolve and become more complex, digital design with a single centralized clock will become far less tractable and convenient. Asynchronous systems provide an attract...

Plasmid for mouse ROSA26 locus for use with plasmid pBigT

2445 — In biomedical research, a very common technique is to alter a mouse’s genome to induce or repress expression of a gene of interest. Although this technology has been around for many years, the actual laboratory work required to produce such a mouse is time-consuming and prone to failure. This technology consists of a plasmid that has been optimally designed to insert any DNA sequence of choice into the mouse genome at the ROSA26 locus. This locus is important because it has a high endoge...

Altering Mouse Genome with pBigT Plasmid

2446 — In biomedical research, a very common technique is to alter a mouse’s genome to induce or repress expression of a gene of interest. Although this technology has been around for many years, the actual laboratory work required to produce such a mouse is time-consuming and prone to failure. This technology consists of a plasmid that includes useful sequences for creating a transgenic mouse, and has been designed for use with the companion plasmid pROSA26PA for targeting the ROSA26 locus. Th...

Phosphodiesterase Inhibitors for the Treatment of Alzheimer's Disease

2439 — Alzheimer’s disease, as the leading cause of dementia, represents a significant health burden. Post-mortem diagnosis of Alzheimer’s patients has established amalyoid beta (A-beta) as playing a significant role in disease progression. A-beta is a small protein fragment that accumulates in plaques in the brain. A-beta is created through enzymatic processing by secretase. The decline in cognitive function in patients with Alzheimer’s is a result of inflammation and damage to neuronal functi...

Producing labeled mouse triglyceride-rich lipoproteins

2507 — Lipid transport and metabolism in the body are important towards the understanding of fat storage/handling and delivery of lipid-soluble drugs. One particular difficulty in the study of blood metabolism of lipid compounds is the unavailability of large amounts of plasma lipid material. Specific Lipoproteins Produced in LPL-Deficient Mice and Purified from Plasma Copyright Available for Licensing and Sponsored Research Support

"Non-antibody cancer therapy using tumor suppressor gene "

2708 — According to the American Cancer Society, the incidence of cancer and the deaths due to cancer remain high. In 2010, over 500,000 Americans might die of cancer and nearly 1.5 million new cancer cases are expected to be diagnosed. As the incidence of cancer continues to rise, cancer therapies are needed more than ever. Conventional chemotherapy is limited by far reaching negative side effects due to the drug’s systemic toxicity that the patient may not be able to tolerate. Therefore, enti...

Mouse for cell lineage tracing in living tissue

2711 — Understanding development and cell lineage are key to combating genetic and developmental diseases. Thus there is a need for new model systems that allow the study of cell lineage. This technology provides a mouse strain that is useful for cell lineage tracing experiments. These mice will also be very useful for monitoring the expression of Cre in living tissues. Furthermore, by using modified forms of Cre whose recombinase activity is inducible, one can use these reporter mice to perfor...

Mouse for osteoporisis studies on bone development and maintenance

2715 — Understanding the process of bone development and maintenance is critical to the treatment of diseases such as osteoporosis. Activating transcription factor 4 (ATF4) is a transcription factor that accumulates predominantly in osteoblasts, where it regulates virtually all functions linked to the maintenance of bone mass. This technology provides an ATF4 KO strain of mice that can be used to study ATF4 function on bone development and organismal metabolism. Conditional ATF4 KO mice are als...

Mouse Antibodies for Immuno-Histochemical Analysis of Prostate Cancer

2738 — Prostate cancer is the most common cancer in men after skin cancer. Early detection of cancers is key to successful treatment. Thus there is a need for improved detection methods. Nkx3.1 is involved cancer initiation, making it a useful marker for the detection and characterization of carcinomas. This technology provides new polyclonal antibodies for immuno-histochemical analysis of prostate carcinoma tissues. The Nkx3.1 homeobox gene has restricted expression in the prostate and ...

Mouse Model to Study Gene Cluster in Chronic Lymphocytic Leukemia and Cell Cycle Progression

2807 — Chronic lymphocytic leukemia (CLL) pathogenesis has been associated with many genetic aberrations. The most common is the deletion of chromosomal region 13q14, which encodes the DLEU2 gene (deleted in leukemia 2), and the miR15-a/16-1 microRNA cluster. A conditional knockout of this entire region was generated simultaneously and was shown to recapitulate the full spectrum of human CLL disease pathogenesis (IR 2807-MDR TechBrief). However, it was unclear whether DLEU2, a gene with unknown...

Foxo 1 Lox Mouse

1192 — Problem or Unmet Need: Type II diabetes is a very complex disease involving many tissues and several key protein components, two of which are insulin receptor and the transcription factor FoxO1. Recently, FoxO1 was determined metabolically as the insulin-regulated transcription factor responsible for insulin action on gene regulation. For this role, FoxO1 is a prime target for drug discovery. In order to study and model the effects of drug action upon FoxO1, knockout mouse lines would be of ...

Insulin 2 GFP mouse

2363 — “Name of the principal inventor: Argiris Efstratiadis Suitable Animal Model for Investigation of Insulin Production In Vivo Transgenic Animal Model Allowing Investigation of Insulin Production and Secretion Research into the insulin- producing beta cell of the pancreas and the expression and secretion of insulin may offer avenues for the development of future treatments for diabetes mellitus, which affects at least 16 million Americans. Insulin synthesis and secretion is regulated by a compl...

Mouse stem cells for cancer drug screening

585 — Rad9 was previously identified by Dr. Lieberman ( ) and promotes cell survival through the regulation of DNA repair and the activation of cell cycle checkpoints induced by DNA damage. Mouse embryonic stem (ES) cells with a targeted deletion of Mrad9, the mouse ortholog of the gene, were created to evaluate the function of the protein in mammals. Mrad9-/- ES cells and Mrad9+/- mice are both available for use in cancer research. Both the mouse and cell lines, with deficient response...

Cutaneous Inflammation and Hyperpigmentation Mouse Study

897 — The skin is responsible for protecting the body from pathogens, temperature regulation, hair growth and vitamin production. Melanin, a brown pigment, is produced by melanocytes and taken up by keratinocytes; the spectrum of human skin color is a result of melanin levels. Increasing evidence has shown that a tyrosine kinase receptor c-kit, and its ligand stem cell factor (SCF) play a major role in skin cell function. SCF has been shown to induce melanocyte proliferation, melanin productio...

Parkinson's Disease Research in Mouse Model

2131 — “Lead Inventor: Parkinson's Disease Screening, Treatment Tested in Mouse Models This mouse model is based on the conditional ablation of Sonic hedgehog (Shh) from mesencephalic dopaminergic (DA) neurons which causes an adult onset, progressive phenotype that recapitulates multiple aspects of the core pathologies of Parkinson's disease (PD): While the basal ganglia are structural and functional unaffected in young adults in this novel model, animals develop late life onset and then progress...

Transgenic mouse for study of macrophages

2568 — The use of knock-out mouse models (where certain genes are deleted) is a critical research tool in understanding gene function. A knock-out animal is created at the embryonic stage of development and global in scope. Not all genes can be effectively studied this way due to severe developmental impairment or even lethality of the knock-out. Thus, there is a need for a more sophisticated knock-out scheme, where tissue targeting is more specific and the knock-out state is switchable. ...

Mouse for prostate cancer drug development

2668 — Prostate cancer is the second leading cause of cancer death in men. Although various therapeutic modalities exist currently (surgical, anti-hormone therapy, etc.) for prostate cancer, malignant and aggressive types of this disease remain refractory to current standard practices. Indeed, current research and development has focused on the formulation of new classes of drugs/compounds that may help improve survival. Animal models of prostate cancer are essential and needed for pre-clinical...

Mouse for human mitochondrial respiratory chain disease

2651 — Mitochondrial respiratory chain disease is a heterogeneous disorder, and several genes including Sco2 have been identified to result in this disease. Sco2 gene mutations cause fatal, early-onset cytochrome c oxidase (COX) deficiency that affects skeletal muscles, heart, kidney, liver, brain and connective tissues. In addition, these gene mutations can result in heart muscle weakening and brain dysfunction. Currently there is no treatment for this disorder, but there are novel drugs under...

TTR-IR Transgenic Mice for Type II Diabetes Treatment Studies

1194 — The lead inventor has generated several lines of different genetically altered mice that aid in researching the role of glucose production and insulin resistance in vivo. In one mouse line, the FoxO1 gene can be conditionally ablated in a tissue-specific, developmental stage-specific, or a combined manner using the Cre-lox method of selection. By crossing these lines with mice expressing Cre under a promoter of interest, FoxO1 can be removed and the effects studied. In another mouse line...

Development of a protocol for infecting mouse immune cells

1908 — T cells are immune cells that circulate in the blood and play important roles in autoimmune diseases, infectious diseases, and some cancers. One novel method of researching how genes function in normal and diseased biological processes is to silence gene expression using RNA interference (RNAi) and observe the resulting phenotype. RNAi involves the introduction of short interfering RNAs (siRNAs) or short hairpin RNAs (shRNAs) to elicit a cell’s innate defense mechanisms to destroy native...

Cell culture technique to produce human and mouse prostate organoids

cu13124 — Prostate cancer is the leading cancer among men in the United States, with an annual incidence of over 144 per 100,000 men, and it is a heavily investigated disease. Most research currently being conducted on prostate cancer relies on the use of established, immortal cell lines to model the disease. However, these laboratory-based cell lines can differ from the actual prostate tissue in a human. Even with prostate tissue obtained via prostatectomy or cystoscopy, current methods fail to maint...

Differentiation of Mouse Embryonic Stem Cells to Motor Neurons

1278 — The degeneration of spinal motor neurons is the underlying factor of a large number of neurological disorders. In order to find treatments for these conditions, it is necessary to understand the development pathways of progenitor cells into motor neurons. Further, an understanding of how to induce stem cells to differentiate into neurons is needed. If a method can be developed to control the differentiation of stem cells into specific neuronal cells, more insight will be obtained into th...

Anti-Thrombotic Agent Testing with Genetically Altered Mouse Model

1957 — One major hurdle hindering antithrombotic drug development is the lack of an appropriate small animal model of thrombosis to test promising therapies, as in vitro models of thrombosis do not accurately recapitulate the hemodynamic conditions, cell-cell interactions, or cell-protein interactions that occur at sites of vascular injury in a living animal. Thus, the development of a “"humanized”“ mouse model of hemostasis and thrombosis would potentially expedite drug discovery and testing a...

"Mouse for luminal stem cells in prostate cancer"

2624 — “Lead Inventors: ; Mouse for prostate cancer diagnosis and risk detection using stem cells: Prostate cancer is one of the most common types of cancer in men. Prostate cancer occurs when cells within the prostate grow uncontrollably, creating small tumors. However, the lineage relationship between normal progenitor cells and cell type(s) of origin for cancer has been poorly understood, which hinders further therapeutic and prognosis development. Adult stem cells are of considerable biolog...

Gene to Identify Wnt Signaling Pathway

730 — The Wnt signaling pathway is a complex network of proteins that plays a role in cancer, embryogenesis, adult neurogenesis and axon guidance. Given its relevance, the Wnt signaling pathway has been under intensive research. There is an ever-growing need for tools to quantify, localize and alter the cellular concentrations of Wnt-pathway molecules to serve as research tools and future therapeutics. and Zeng Li Available for Licensing and Sponsored Research Support

Transgenic mouse for impaired expression of endogenous ZDHHC8 as Marker for Schizophrenia

1806 — Microdeletions in chromosome region 22q11 are associated, with relatively high frequency, with severe mental illness. Whereas a person in the general population has a risk of about 1% of developing schizophrenia, that risk may be 25-30 times higher in persons having a deletion in the 22q11 region. It therefore seems likely that the 22q11 region harbors genes that, alone or in combination, are causally implicated in schizophrenia. An emerging “"genetic”“ picture is that the 22q11 micro...

Murine Model for Charcot-Marie-Tooth Disease Type 2E

2977 — Charcot-Marie-Tooth Disease Type 2E (CMT2E) is a currently incurable disease characterized by progressive degeneration of peripheral motor and sensory neurons that first manifests itself in late childhood or early adulthood. It is known that the disease is caused by mutations in the neuronal intermediate filament protein (NEFL) gene; however, a lack of studies correlating disease onset with anatomy or histology and a lack of published autopsy results regarding disease progression has com...

Genetic Pharmacotherapy for Target Validation in Neuropsychiatric Disorders

2931 — Drug discovery for neuropsychiatric disorders is a time and resource intensive process. This technology would provide the necessary tools to validate drug targets of interest in mouse models of neuropsychiatric disorders prior to their development. This technology utilizes mouse lines that can temporally and spatially reduce protein expression. The reduction demonstrated by this system is comparable to the levels of reduction seen when treating with high affinity drugs in vivo. Mo...

Asynchronous Pipeline with Latch Controllers for Reduced Control Delays and Latch Delays

m01-020 — “Name of the inventor: Steven Nowick Asynchronous Pipeline System Uses Simple Transparent Latches to Deparate Data Items Asynchronous pipelines for high-speed applications which use blocks of static logic for processing data are described. The system uses simple transparent latches to separate data items. Pipeline has Simplified Control, and Reduced Control Delays and Latch Delays The processing stage in an asynchronous pipeline comprises a latch controller and a data latch. The latch contr...

Nitrocellulose-Based or Hydrogel-Based Microarrays for Identifying Infection

1170 — The kit detects the presence and amount of agents in a sample that determines infection in a subject. The kit also detects whether an agent known to specifically bind to a first compound also specifically binds to a second compound. Further, the method also provides diagnostic methods using instant antibodies. Microarrays for Study of Molecules Needed to Advance Proteomics and Glycomics Name of the inventor: Denong Wang Ph.D. Methods of making and using novel nitrocellulose-based o...

Post-surgical cancer recurrence prevention by inhibition of metastatic cell tumor growth

1642 — This invention provides a method of preventing the proliferation of metastases and following surgery appears to be due to proteolytic cleavage mediated by matrix metalloproteinase 9 lrena Kirman, MD, Ph.D. and Richard L. Whelan, MD United States Issued Patent# 7166,288 and patent pending Licensing Status: Available for Licensing and Sponsored Research Support Publications: Surgery (2004) 136 (2): 205-9; Disease of the Colon and Rectum (2004) 47 (6): 91 1-1 8; Surg En...