Available Technologies

Atherosclerotic cardiovascular disease and Alzheimer's disease therapy

1615 — Altered lipid metabolism is associated with coronary cardiovascular disease and Alzheimer’s disease. Accumulated evidence suggests that cholesterol and cholesterol-loaded macrophage foam cells play a critical role in the development of these disorders. The cause of cholesterol accumulation in macrophage foam cells is not completely understood, but likely a result of imbalanced cholesterol transport into and out of the macrophage. High density lipoprotein (HDL) accounts for the major prop...

Cell delivery platform for cardiovascular repair

2429 — Cardiovascular diseases are responsible for a preponderance of health problems in many countries. Cell and stem cell therapy are promising new treatment strategies for many cardiovascular diseases, such as acute myocardial infarction (AMI) and heart failure (HF), however the current methods to transplant cells into myocardium are hampered by low survival and retention of transplanted cells, resulting in limited beneficial effects. This technology describes a method to generate ful...

Treatment of atherosclerosis in cardiovascular disease

2556 — Cardiovascular disease is the leading cause of death in the United States, affecting over 80 million persons and representing the cause of a third of annual deaths. Indeed the market for treatment of hyperlipidemia, a cause of atherosclerotic disease, remains one of the largest in medicine, estimated at ~$15 billion in 2004 and growing to over $25 billion by 2015. Although HMG-CoA inhibitors (statins) have been the mainstay of lipid treatment in cardiovascular disease, much interest has ...

Cell Lines from Adult Human Ventricular Cardiomyocytes for Cardiac Research

823 — Current cardiac research is restricted by very limited cell sources, as human primary cardiomyocytes have a finite life-span in culture before becoming terminally differentiated. Attempts to immortalize ventricular cardiomyocytes in order to establish a proliferating human cardiomyocyte cell line for research have not been successful. This technology established a ventricular cardiomyocyte cell line from human primary cardiomyocytes by a novel mitochondrial function-based immortalizat...

System and Methods for Electromechanical Wave Imaging of the Cardiovascular System

1781 — Assessment of cardiac wall motion by imaging rapid transient motion of tissues: Diagnostic information could be obtained by analyzing the local motion of cardiovascular tissues over the course of an entire cardiac cycle. This motion results from various transient events such as the valves closing/opening, sudden changes in blood pressure and electrical conduction of the myocardium. The transient motion generated by most of these events occurs within a very short time (on the order...

Real-Time Diagnostic Assays for Cardiovascular Shock using Neuro-Humoral Factors

1875 — Tardy diagnosis of cardiovascular shock can be life-threatening resulting in a need for rapid and accurate assessment in order to deploy treatment. This technology assays neuro-humoral factors (NHF), hormones that regulate blood pressure, to detect early signs of shock in real-time. It consists of the preparation of capture agents, which bind to NHF for assay use and the possible configurations of the assay. With this NHF assay real-time diagnosis of cardiovascular shock and subsequent treat...

System and Methods for Electromechanical Wave Imaging of the Cardiovascular System

1963 — Extremely valuable diagnostic information could be obtained by analyzing the local motion of cardiovascular tissues over the course of an entire cardiac cycle. This motion results from various transient events such as the valves closing/opening, sudden changes in blood pressure and electrical conduction of the myocardium. The transient motion generated by most of these events occurs within a very short time (on the order of milliseconds) and cannot be acceptably imaged with conventional ...

System and Methods for Electromechanical Wave Imaging of the Cardiovascular System

2442 — Extremely valuable diagnostic information could be obtained by analyzing the local motion of cardiovascular tissues over the course of an entire cardiac cycle. This motion results from various transient events such as the valves closing/opening, sudden changes in blood pressure and electrical conduction of the myocardium. The transient motion generated by most of these events occurs within a very short time (on the order of milliseconds) and cannot be acceptably imaged with conventional ...

Pseudo Random Arterial Spin Labeling for Cerebral Blood Flow Detection

1474 — Cerebral blood flow (CBF) is one of the most important physiological variables in understanding local brain metabolism. By detecting changes in blood flow, regions of the brain with increased blood oxygen requirements can be identified - this is the most frequently used method to estimate changes in neural activation. Previously CBF measurements have used PET, CT or magnetic resonance imaging (MRI) to detect radioactive tracers or radiographic or MR contrast agents administered to the pa...

A New Use of Clenbuterol in Treating Congestive Heart Failure (CHF)

1509 — Details of the Invention The invention establishes that adrenergic beta-2 agonists such as clenbuterol can be used to prevent and treat heart failure patients either alone or in combination with an adrenergic beta-1 antagonist such as metoprolol. Clenbuterol is a long-acting beta 2-adrenergic agonist approved for use in the treatment of pulmonary disorders in Europe. Oral clenbuterol has been also used extensively by athletes to enhance muscle size and strength. This new therapy will prov...

Congestive Heart Failure Treatment with Clenbuterol

1675 — The invention establishes that adrenergic beta-2 agonists such as clenbuterol can be used to prevent and treat heart failure patients either alone or in combination with an adrenergic beta-1 antagonist such as metoprolol. Clenbuterol is a long-acting beta 2-adrenergic agonist approved for use in the treatment of pulmonary disorders in Europe. Oral clenbuterol has been also used extensively by athletes to enhance muscle size and strength. This new therapy will provide a unique strateg...

An Antithromibotic Agent

357 — “Name of the inventor: David Mark Stern. Preventing Thrombosis without Affecting Normal Hemostasis Calreticulin is a polypeptide that was found to bind Factor IX/IXa and prothrombin. This invention covers a means of using Calreticulin for blocking or preventing thrombosis in a subject without affecting normal hemostasis. Calreticulin Used i...

Oral Clobazam for Treatment of Post Stroke Hypertonia

2174 — “Lead Inventor: Randolph S. Marshall Hypertonia Hinders Recovery in Stroke Patients: Approximately 750,000 patients suffer a stroke in the United States annually. Of these, about two-thirds require rehabilitation for sequelae related to CNS damage, including aphasia, paralysis, and hypertonia. In 2003, there were over 4.7 million patients in the U.S. living with chronic stroke. Of those with hemiparesis, 63% developed hypertonia. Hypertonia, is a condition in which muscles maintain a leve...

Treatment of Inherited and Genetic Cardiomyopathies by ERK Inhibition

2372 — Emery-Dreifuss Muscular Dystrophy (EDMD) is a form of genetic, degenerative muscular dystrophy disease affecting muscles used for movement (skeletal muscles) and heart (cardiac) muscle. The major cause of mortality and morbidity in EDMD is cardiomyopathy. So far, no specific treatment for EDMD exists. While EDMD is a relatively uncommon disorder, mutations in the same gene (LMNA) that cause autosomal dominant EDMD may in fact be responsible for 8% or inherited and sporadic dilated cardio...

Vesselostomizer: Device and method to create a smooth opening on a tubular structure such as an artery or a vein

395 — With traditional surgery techniques, it is difficult and time consuming to create a smooth, regular fenestration on a vessel with a predictable diameter. The device described in this technology comprises an elongated circular knife, an inner channel and an elongated probe. The elongated probe is disposed within the inner channel of the elongated circular knife and being adapted to be movable axially and rotatably and a perpendicular bar formed on the distal end of the elongated pr...

Early detection of irregular heart beats using implantable cardiac defibrillators (ICDs)

2952 — The technology computes the dominant frequency (DF) and dominant frequency spatial derivative (DFD) of an individual’s heart rate, indices useful for measuring the electrical activation of the heart. When an abnormally fast heart rate caused by ventricular tachyarrhythmia (VTA) is detected, the technology will enable the ICD to quickly and accurately classify the heart rate as originating from one of 3 tachycardias: monomorphic re-entrant ventricular tachycardia (MVT), ventricular fibril...

Vascular disease non-invasive prevention and treatment

1695 — “Name of the inventor: Martin David Tilson III Cardiovascular disease, peripheral vascular disease, or aneurysm prevention and treatment The inventors have identified a nutraceutical formulation which inhibits abdominal aortic aneurysm (AAA) related matrix metalloproteinase-2. The invention encompasses methods for treating AAA, or other similar vascular conditions, by administering safe and effective amounts of a nutraceutical for clinical treatment. Various methods for administration ...

Heart Geometrical Measurements

2215 — Postinfarction reentrant ventricular tachycardia is an important clinical problem; a major problem in treatment is determining the location and geometry of the circuit. Models to aid in mapping of the reentrant circuit have been encumbered by complex, difficult to measure variables. A simpler model that relies upon easily measured variables would improve basic tachycardia research and the development of therapeutics. The invention is a geometrical formulation of the relationship b...

Endoscopy using balloon catheter with radionuclide and chelating agent to prevent restenosis

631 — “Name of the inventor: Judah Z. Weinberger Prevention of restenosis after arterial intervention: An apparatus and associated method for treating a disease process in a luminal structure of a subject is described. A complex of a radionuclide and a chelating agent in an amount effective to inhibit the disease process is also disclosed. Radionuclide and a chelating agent for use with balloon catheter procedures: The complex is administered into a luminal structure by a balloon catheter. ...

Echocardiogram Video Image Processing

m00-052 — “Name of the inventor: Shih-fu Chang Echocardiogram Image Indexing and Summarizing System Description: A Method and system for indexing and summarizing echocardiogram images is described. Video indexing and summarization are also described. Summarization Method is Tool for Efficient Access and Browsing of Echocardiogram Video The method for processing an echocardiogram video of a patient's heart involves receiving sequences of consecutive video frames and monitoring notable occurrences in e...

Novel Protein Increases Resistance to Viral Infections

1300 — Virus infections are very common infective diseases and exceptionally widespread. The existing approaches to fight severe virus infections do not generate expected cure rates or quality of life. In addition, current approaches have some side effects, such as drastic shutoff of host function. Therefore, there is unmet need in the market for new innovative products. This invention identified a new protein that could inhibit virus replication and increase resistance to virus infection, whic...

Compounds for preventing restenosis after angioplasty or stent implantation

1911 — Related Technologies: IR# & IR# Prevention of vascular stenosis and restenosis in diabetic patients resistant to rapamycin : This technology provides new therapeutic strategies useful for the treatment and prevention of vascular stenosis and restenosis in diabetic and obese patients. Recent studies suggest that rapamycin resistance in diabetic and obese patients may be due to their elevated blood leptin levels. In addition, new research reveals that phosphatidylinositol 3-kin...

Myocardial revascularization through the endocardial surface using a laser

260 — Despite advances and novel therapeutics, ischemic heart disease remains a major health problem in the developed world. Eligible patients can be treated by cardiac revascularization using stents, coronary artery bypass grafting or coronary artery balloon dilatation following acute heart attack. However, patients with extensive coronary atherosclerosis in whom bypass surgery is not possible have limited treatment options. Both treated and ineligible patients will eventually develop chronic...

Luminal Structure Disease Treatment

853 — “Name of the inventor: Judah Z. Weinberger Balloon Catheter for Radioactive Dose Control: The central balloon may be separately inflated temporally and with different radioactive fluid than the edge balloons. Other arrangements include a wire, stent and concentric balloons, which provide spatial and temporal control enabling differential radioactivity at different spatial locations along the structure. Arterial Trauma Redu...

Intravascular Systems for Corporeal Cooling

882 — “Name of the inventor: Arthur E. Schwartz MD Intravascular Catheter Systems for Corporeal Cooling: The method of treating a patient involves positioning the distal portion of a corporeal cooling catheter within the patient's affected organ and providing cooled blood through the catheter into the internal part of the organ. The intravascular catheter systems for corporeal cooling are specially characterized with a pressure dependent valve, balloons with variable inflation, an annular in...

Intravascular Systems for Corporeal Cooling

891 — “Name of the inventor: Arthur E. Schwartz MD Intravascular Catheter Systems for Corporeal Cooling: The method of treating a patient involves positioning the distal portion of a corporeal cooling catheter within the patient's affected organ and providing cooled blood through the catheter into the internal part of the organ. The intravascular catheter systems for corporeal cooling are specially characterized with a pressure dependent valve, balloons with variable inflation, an annular in...

Thrombotic, Ischemic Disorders Treatment

924 — Lead Inventor: CD39/Ectoadpase reduces severity of ischemia by inhibiting thrombosis Platelets accumulate at wound sites and form blood clots, a process called thrombosis, in order to reduce bleeding. However, excessive platelet accumulation can restrict blood flow to such an extent as to cause ischemia, a loss of oxygen in body tissue that results in tissue degeneration and disorders such as stroke. The current technology has identified a new method to prevent this pathological thrombo...

Treating and Preventing Heart Tissue Degeneration

1435 — “Name of the inventor: Hina Chaudhry Heart Tissue Degeneration Treatment The method for treating or preventing heart tissue degeneration in a subject involves a cyclin-associated agent in an amount effective to treat or prevent heart tissue degeneration. The method also provides a therapeutic composition, comprising a cyclin-associated agent and optionally, a pharmaceutically-acceptable carrier and a kit for delivering cyclin-associated agent to the heart tissue cells. Heart Disease T...

Reentrant Ventricular Tachycardia Isthmus and Shape for Catheter Ablation Indentification for Ventricular Tachycardia Treament

1183 — “Name of the inventor: Edward J. Ciaccio Reentrant Circuit Isthmus and Shape for Catheter Ablation Identified A system and method for identifying and localizing a reentrant circuit isthmus and shape for catheter ablation during sinus rhythm is described. The method for identifying and localizing a reentrant circuit isthmus involves receiving and storing electro-gram signals from the heart of a subject during sinus rhythm via electrodes, creating a map based on the stored electro-gram sig...

Human mesenchymal stem cells promote cardiac repair for cardiac disorders

1648 — “Name of the inventor: Ira S. Cohen Cardiac disorder treatment with progenitor cells and cardiogenic cells Method for treating a subject afflicted with a cardiac disorder and related articles of manufacture are described. The method comprises inducing differentiation of a progenitor cell, in-vitro, to a cardiogenic cell and administering a therapeutically effective amount of a cardiogenic cell to the subject, thereby treating the cardiac disorder in the subject. The method is signi...

Cardiac repair and myocardial infarction treatment with human stem cells

1662 — “Name of the inventor: Michael Rosen M.D. Stem cells treat cardiac disorder and myocardial infarction A method for treating a subject afflicted with a cardiac disorder and for determining whether an agent stimulates/inhibits myocyte proliferation is described. The method for treating a subject afflicted with a cardiac disorder comprises producing a solution comprising media conditioned from the culture of cells and administering the solution to the subject, thereby treating the cardia...

Stable suspension of microbubbles for wound treatment

m10-026 — Microbubbles, colloidal particles of size smaller than 10 microns, have a variety of applications in ultrasound imaging, targeted drug delivery, DNA loading, and oxygen delivery. Providing intravenous oxygenation of the blood stream is critical for promoting wound healing, treating stroke, and enhancing the therapeutic index of radiation therapy. This has the potential to revolutionize the critical care of both pediatric and adult illnesses. One of the key hurdles of this technology invo...

Vascular stapler for anastomosis

2713 — The reconnection of blood vessels, also known as anastomosis, during surgery is pivotal and time consuming. The current surgical method employed involves manually sewing the free ends of the blood vessels together, an operator dependent task that can take up to fifteen minutes. In surgical transplantation of the liver for example anastomosis of the donor organ blood vessels to the recipient should occur as fast as possible in order to restore blood flow. In this example prolonged time wi...

Targeted Microbubble Shell Preparation for Ultrasound Molecular Imaging and Targeted Therapies

m10-094 — A microbubble is a gaseous colloidal particle with diameter less than 10 um, of which the surface comprises amphiphilic phospholipids self-assembled to form a lipid monolayer shell. Due to the compressible gas core, microbubbles provide a sensitive acoustic response. They serve as echo contrast agents for ultrasound imaging, as drug delivery vehicles for targeted therapy, and as gas carriers for blood oxygenation. Designing and engineering non-immunogenic, ultrasound-triggered microbubbl...

Diabetic Complications Treatments

2981 — Diabetes is one of the most common chronic disorders, affecting 1 in 12 individuals in US. Although rapid progress in drug development has transformed diabetes from a fatal to a manageable disorder, it has simultaneously resulted in an increased number of long-term complications. For example, cellular swelling is a chronic condition that previously would not have had time to manifest in diabetes patients. The current rise in long-term complications thus underscores the need for the devel...

Luminal Structure Disease Treatment

813 — “Name of the inventor: Judah Z. Weinberger Balloon Catheter for Radioactive Dose Control: An apparatus for treating a disease process in the vicinity of a luminal structure using a balloon catheter including radioactive material is described. The balloon catheter has a shaft and an inflatable balloon. The tube of the catheter is adapted to include a radioactive material for producing radiation for treating a disease process. The tube segment produces a radiation dose which varies along a...

Parallelized Wireless Electrophysiology

m11-125 — Understanding the workings of the nervous system has long been considered one of the greatest challenges for modern biology. While high accuracy single cell electronic recordings have helped increase our understanding, large-scale massively parallel information recordings from a large number of cells, necessary for a more complete understanding of the nervous system, have thus far been elusive. Primary roadblocks to improving our understanding at this scale have been the large size and w...

Image Quality Assessment in CT Scans of Heart Using Gated Protocols

2271 — The invention is an apparatus capable of performing an objective, quantitative evaluation of CT performance when using gated protocols. The major components of the apparatus consist of a motion assembly, which mimics the motion of the heart, and a phantom capable of measuring accepted CT performance parameters. The phantom component of the apparatus can be replaced with other commercially available CT phantoms. Patent Pending (WO/2009/067687) ~ see links below. Av...

Synthesis of Resveratrol-based Compounds

m09-015 — Recent studies have shown that resveratrol, a polyphenol antioxidant found in red wine, possesses an impressive range of biological activities against diverse and complex medical conditions such as diabetes, inflammation, Alzheimer’s disease, cancer, cardiovascular disease and aging. While resveratrol has been the focus of ongoing research in both academic and industrial laboratories, little effort has been devoted to studying the large family of resveratrol-based oligomers or to synthes...

Use of an omega-3 lipid-based emulsion following ischemic injury to provide protection and recovery in human organs

1926 — This invention describes a therapeutic intervention in the treatment of organ ischemia to prevent the cell death following the insult. The intervention is the injection of intravenous omega-3 fatty acid rich lipid emulsions. These emulsions have potential uses in medical situations which require rapid delivery of long chain unsaturated omega-3 fatty acids, i.e., EPA and/or DHA, to organs. ; ;

Obesity Treatment from Biological Factors

m03-005 — “Lead Inventors: , Dr. Hailong Zhang, Zhiru Yang Obesity Prevention: Obesity is a growing health issue worldwide. In the US, 30% of the adult population is considered obese, while another 35% is considered overweight. Obesity leads to an increased risk of type 2 diabetes, cardiovascular disease, and a host of other health issues. While the American diet in combination with a lack of physical exercise contributes much to this growing epidemic, biological factors are also at work. Therefore...

Novel biochemical markers of myocardial ischemia

523 — Ischemic heart disease is the leading cause of death in the developed world. Patients with angina or other signs of acute myocardial disease are a common sight in emergency rooms. These patients would benefit immensely from the availability of rapid diagnostic tests that can accurately determine the acuteness of their condition and report their risk for imminent heart failure. Early identification of high-risk cases would lead to immediate treatment of the patients whose life depends on ...

Molecular Pacemakers for Heart, Brain

748 — Ion channels, a group of specialized proteins in the membranes of nerve and muscle cells, play essential roles in the physiology of all cells. In recent years ion channels have been implicated in a long list of diseases, including cystic fibrosis, diabetes, cardiac arrhythmias, neurologic and psychiatric diseases, gastrointestinal disorders, and hypertension. Hyperpolarization-activated cyclic nucleotide gated (HCN) channels, which are often referred to as pacemaker channels, help genera...

Drug for treating or preventing heart failure

1919 — “Lead Inventor: Heart failure treatment protects against heart failure in animals: While progress has been made in the treatment of various cardiovascular diseases, the increasing incidence of heart failure (a syndrome resulting from long-term cardiac disease) in combination with an aging population demands better therapeutic and preventative strategies. Phosphodiesterase 4D deficiency in receptors that regulate calcium channel functioning in cells has recently been linked to increased h...

New Method to Prepare Antioxidant Flavonoid Derivatives

m08-023 — Lead Inventors: , Problem or Unmet Need: Age-related macular degeneration (AMD) is the leading cause of blindness in the United States particularly among people over 65 years old. Although vitamin supplements and diet changes have been shown to slow the progression of this disease in some clinical studies, there are no effective therapies currently available for genetic or dry (non-neovascular) age related macular degeneration. The majority of patients still face progressive loss of cen...

Reducing Inflammation in Respiratory Tract Infections with Calpain Inhibitors

2286 — Respiratory tract infection is a major cause of death in the US. It can be the result of both the direct damage caused by a pathogen and the indirect damage caused by the excessive inflammatory response to infection or trauma. Bacterial infections can be treated with antibiotics, but an excessive inflammatory response is difficult to control. Effective methods are necessary to reduce inflammation in the treatment of respiratory infections. This technology describes a method for re...

Obesity treatment targets acetyl-CoA carboxylase (ACC) enzyme

m10-006 — Acetyl-coenzyme A carboxylases (ACCs) are central to the fatty acid metabolism and are therefore promising targets for the development of therapeutic agents against obesity, diabetes, and other symptoms of the metabolic syndrome. ACC is a large, multi-domain enzyme in most eukaryotes. The activity of the enzyme is controlled by small molecule modulators at the transcriptional level. Two distinct classes of compounds, as illustrated by haloxyfop (FOPs) and tepraloxydim (DIMs), are potent ...

Wireless Handheld Optical Probe for Breast Cancer Imaging

cu12093 — Breast cancer affects approximately 1 in 8 women in the United States and the incidence of breast cancer throughout the world is increasing. With more than 200 000 new cases every year, it accounts for 28% of all new cancers diagnosed in women. Because of growing awareness, more women today are undergoing breast cancer screening, such as x-ray mammography. However, there have been noted cases of poorly maintained mammography machines emitting excessive x-ray radiation that can lead to ca...

Diabetes management through oral anti-inflammatories

1497 — Despite many advances in treatment, Type 2 diabetes is one of the largest health problems worldwide. Approximately 24 million Americans are afflicted, costing an estimated $116 billion in direct medical costs and nearly $60 billion in disability, lost productivity, and premature mortality. Effective diabetes management is complex, expensive, and demands a high level of commitment from the patient. Clearly, there is a great need for improved treatment strategies, particularly those that a...

Genetic terminal disease treatment without negative immune response

1523 — In medicine, particularly for treatments of terminal diseases, there is a need for the ability to modify the genetics of cells. It is a well-known problem that by trying to insert foreign genes into a person’s cells, an immune response is thereby triggered, which can nullify the effects of the foreign genes. This problem has been a hindrance to the development of life-saving genetic treatments for cancer, heart disease and many other degenerative diseases. Therefore, there is an unmet ne...