Available Technologies

Glycan Array for Immunoassay, Pathogen Detection, Infectious Disease Identification, and Vaccine for Anthrax and Other Diseases

1985 — This photo-activated glycan array could be used to develop immunoassays to detect pathogens and identify infectious diseases. The array targets the complex sugars pathogens carry on their surfaces - carbohydrates that are specific to each pathogen and less mutable than the than resident proteins traditionally targeted in disease identification and pathogen detection. Using the array, researchers have identified the immunogenic sugar moieties of anthrax () spores, enabling the rapid...

Diagnostic biomarker for Rolandic epilepsy

2463 — Epilepsy is a complex but common neural disability that affects 1 in 100 people. Rolandic (or childhood) epilepsy is a common subtype of the disorder. One of the most fundamental problems in the treatment and research of rolandic epilepsy is clear and proper diagnostic criteria. While electroencephalographic (EEG) recordings have been utilized, the EEG abnormality used for diagnosis of rolandic epilepsy is also associated with other neural developmental disorders, reducing the reliabilit...

Turkey Viral hepatitis diagnostic biomarker

2589 — Turkey viral hepatitis (TVH) is an acute, highly contagious and often subclinical disease of turkey. It is widespread causing reduced fertility and mortality in turkeys. The disease is highly contagious; therefore, rapid response to infection is important for minimizing the impact. Currently the disease is diagnosed by post-mortem lesions, which takes place after infection in the Turkey population. In addition, no treatment is available for this disease. Therefore, there is a need for a ...

Biomarker for Diagnosis of Chronic Kidney Disease

2311 — Establishing whether a patient has chronic kidney disease versus acute kidney injury is currently difficult because the two ailments initially present similarly. Acute kidney injury is imminently life threatening requiring the patients be admitted to the hospital while this is not the case for chronic kidney disease. Although subsequent examinations can establish which disease is present, the process is time consuming. A method to rapidly, specifically test whether a patient has chronic ...

Metabolite Biomarker to Regulate Cancer Cell Growth

m10-032 — Cancer cells differ from most adult cells in their high uptake of glucose. The glucose is subsequently converted into lactate even in the presence of oxygen, allowing cells to accumulate glycolytic intermediates for cell biosynthetic processes. A key enzyme in the glycolytic pathway, pyruvate kinase M, has been implicated in determining the metabolic phenotype of cancer cells as opposed to normal adult cells. Pyruvate kinase M mRNA is alternatively spliced to produce two isoforms of the ...

Bio-Immunosay (BIA) Kit for Research and Diagnosis

126 — Biomolecule binding assays are staples of research and are widely used in clinical diagnostic tests. For instance, ELISA type binding assays are frequently used in screening for HIV and other pathogens. The tests rely either on a biological binding agent, such as a receptor with an affinity for the target ligand, or on an antibody against the ligand to form a complex with the target. The receptor or antibody can be fixed to a substrate and the degree of binding determined via a number of...

Detection and isolation of human malignant cells

379 — According to the American Cancer Society, the incidence of cancer and the deaths due to cancer still remain high. In 2009, nearly half a million of Americans might die of cancer, more than 1,500 people a day, and approximately 1.5 million new cancer cases are expected to be diagnosed in the next year. Malignant cell detection is a key factor in effective cancer diagnosis and research. The current methods for malignancy identification are generally expensive and time consuming and accordi...

Detection of High Grade Cervical Lesions and Cancers by Novel PCR-ELISA Assay

449 — In the US alone, over 10,000 women are diagnosed with cervical cancer annually. The Pap test remains the most effective method in detecting such cancerous or precancerous lesions. Infections caused by high-risk strains of Human Papilloma Virus (HPV) constitute the major cause of cervical cancer. However, despite extensive knowledge of the genetic signatures of these strains, there is still great need for simple and automated methods for detection of high-risk strain infection. Thi...

Diagnosing Capillary Leak

476 — “Name of the Inventor: Bashir Zikria Capillary leakage detection by measuroing biomarker protein concentrations: Within the past decade there has been increasing evidence clinically and experimentally for the presence of generalized leaky capillaries in most ischemia- reperfusion injuries, shock syndromes, sepsis, cardiopulmonary bypass in infants, etc. So far there has been no test to diagnose the presence of generalized leaky capillaries. Diagnosis of capillary leakage using FITC-al...

Diagnostic Testing of MUM-1, MUM-2 Chromosomal Abnormalities for Multiple Myleloma

611 — Multiple myeloma (MUM) is a cancer of plasma cells and is the second most common blood-borne cancer in the United States. This type of cancer is commonly due to chromosomal breakage and mis-rearrangement, causing overexpression of tumor-inducing oncogenes. Since multiple myeloma can present similarly to other more benign disorders of plasma cell proliferation (i.e. myoclonal gammopathy, etc.), diagnostic tests which can accurately detect the type of chromosomal abnormality present are ne...

Diffuse Large Cell Lymphoma Treatment

718 — Diffuse Large Cell Lymphoma (DLCL) is a fast-growing, aggressive form of non-Hodgkin lymphoma (NHL), a cancer of the body’s lymphatic system. The standard treatment of DLCL is chemotherapy and radiation therapy, which have a lot of side effects. In addition, the treatment and prognosis depends on accurate diagnosis and staging information. Conventional diagnostic method is biopsy of patient tissues, which has its limitations in tissue sampling, patients' tolerability and diagnostic effic...

Urinary Diagnostic Marker for Detection of Menopause

728 — Menopause, the condition when ovulation ceases and disruption of the neurohormonal axis has occurred, affects all women and can be associated with significant medical symptoms such as insomnia, depression, osteoporosis, etc. Indeed, the market for hormone replacement therapy (HRT) for treatment of menopause-associated conditions reached $5 billion in 2003 and continues to grow at an estimated CAGR of 5.3%. Currently the condition of menopause is diagnosed using clinical criteria using pa...

PPH1 Gene's Role of in Familial Primary Pulmonary Hypertension (FPPH)

1071 — Familial Primary Pulmonary Hypertension (FPPH) is a rare autosomal dominant disorder. It is characterized by monoclonal plexiform lesions of proliferating endothelial cells in pulmonary arterioles that lead to elevated pulmonary artery pressures, right ventricular failure, and death. The disease can occur from infancy throughout life with a mean age of onset of 36 years and has a 2:1 ratio of affected females to males. Without intervention, the median survival is less than three years af...

High Resolution Metabolic Brain Imaging for Alzheimer's Diagnosis

1289 — In order to diagnosis Alzheimer’s in its early stages and to subsequently monitor its progression, a technology is needed that can detect Alzheimer’s using medical imaging techniques. Such a detection technique would not only require knowledge of how Alzheimer’s affects the brain over time, but also of how to image that change. Research comparing age-related memory decline in monkeys and humans has demonstrated that, while much of the hippocampus deteriorates with age, it is the decline ...

Atherosclerotic cardiovascular disease and Alzheimer's disease therapy

1615 — Altered lipid metabolism is associated with coronary cardiovascular disease and Alzheimer’s disease. Accumulated evidence suggests that cholesterol and cholesterol-loaded macrophage foam cells play a critical role in the development of these disorders. The cause of cholesterol accumulation in macrophage foam cells is not completely understood, but likely a result of imbalanced cholesterol transport into and out of the macrophage. High density lipoprotein (HDL) accounts for the major prop...

A Method for Using Molecular Networks in Genetic Linkage Analysis of Complex Disorders

1750 — The technology is a method that could significantly improve the currently used genetic analysis approaches by using the growing in size and quality knowledge about molecular function and molecular networks. Andrey Rzhetsky STV Reference: IR 1750 and IR 1902

Gene expression profiling for perinatal nutritional health assessment

1833 — Currently, nutritional assessment in a newborn baby is essentially limited to birth weight. This measure is crude and only a basic gauge of prenatal growth; some infants may fall into normal weight ranges and still be suffering from particular micro- or macro-nutrient deficiencies. Conversely, some neonates of low birth weight may be entirely healthy, and simply reflect normal statistical variation. As such, birth weight may be said to have poor sensitivity and specificity. The in...

Type-2 diabetes diagnosis and treatment

1924 — The technology implicates the Ll gene and its human ortholog (Clorg32) in susceptibility to type-2 diabetes. Furthermore, it provides methods for reducing diabetes susceptibility and increasing the expression of LL or CLORF32 in a subject. In addition, the technology provides a method for identifying agents that modulate the expression of Ll RNA or Clorf32 RNA. The identification is accomplished by determining and comparing the expression of Ll RNA or Clorf32 RNA in the presence and the ...

Diagnostic Test for Chronic Obstructive Pulmonary Disease (COPD)

1952 — One of the key measurements in Chronic Obstructive Pulmonary Disease (COPD) diagnosis is lung elastin degradation which occurs with the development of pulmonary emphysema. Current measurements of elastin peptides are dependent on immunoassays, which have varied specificity with different antibodies. Therefore, there is a need for standardized methods of accurately detecting and measuring elastin components for the purpose of diagnosing and/or treating COPD, chronic bronchitis, emphysema,...

Two-Pore Domain Channels as Regulators of Proliferation in Prostate Cancer

1974 — Most cancer cell markers have cross-reactivity to non-cancerous cell lines of the same tissue type. This can be deleterious to the identification of cancer cells for diagnostic and research purposes. In addition, determining if the cells are still proliferating can alter results, hinder treatment, or generate a misdiagnosis. Tools are needed that will allow scientists and doctors to identify proliferating cancerous cell lines in vitro, in situ, and in vivo. Importantly, these tools need ...

Secreted Beta-Amyloid Precursor Protein Cleavage Fragment as Diagnostic Marker of Neurodegenerative Disease

2015 — Alzheimer’s disease is the leading cause of neurodegenerative dementia, affecting over 35 million persons worldwide. The costs of care for this disease are enormous with direct healthcare costs estimated at $25 billion as well as indirect caregiver costs at $36.5 billion due to lost productivity. Unfortunately, few diagnostic tests currently exist which can detect early onset of this disease in order to provide better care and therapy. The diagnostic gold standard of Alzheimer’s disease ...

Drop-on-Demand in a Microfluidic Chip

m07-100 — Lab-on-a-Chip to Control Single Fluid Drops on Microfluidic Chip: The in-chip drop-on-demand technology allows for high frequency (2.5 kHz) triggering and controlled delivery of small single drops (pL * nL) on demand. This technology offers an attractive alternative design and method for microfluidic chip drop dispensation. For the encapsulation application, the technique uses piezoelectric actuators to dispense extremely precise amounts of fluid with pico-liter accuracy into a mi...

Diagnosis and Identifying Therapeutics for Alzheimer's Disease

2312 — Although various diagnostic tests exist to detect Alzheimer’s disease (AD), a major hurdle in developing anti-AD drugs is the lack of a defined causative event in the genesis of the disease. Thus there remains a need for improved methods of diagnosis of AD and for methods to identify compounds suitable for the treatment, prevention or inhibition of AD. Numerous hypotheses have been proposed in the pathobiology of AD. Mutations in certain genes is known to cause or increase the risk of...

Micro RNA expression profiling for human acute myeloid leukemia diagnosis

2348 — In 2009, 45,000 new cases of leukemia were diagnosed and 22,000 deaths occur annually as result of the disease. Acute myeloid leukemia (AML), a blood stem cell cancer, is one of the most prevalent and aggressive forms of leukemia and 13,000 new cases were diagnosed in 2009. Early detection is critical to AML treatment and sensitive multiplex diagnostic tools are necessary for clinical and laboratory applications. MicroRNAs are small endogenously encoded RNAs that negatively regulate gene...

DNA Methylation Profiling Method

2354 — In the effort to gain insight into whole genome methylation patterns, their biological functions and their abnormality in human disease, various methylation profiling technologies have been developed. However, existing methods have either limitations or severe drawbacks. Traditional bisulfite conversion suffers from variability due to incomplete conversion, over-conversion, DNA degradation, and low yield. The ideal whole genome methylation profiling method would combine ultrahigh through...

Diagnostic Biomarkers for Autism Spectrum Disorder

2368 — This technology provides methods to detect autism spectrum disorders (ASD) earlier than current methods that rely on behavioral assessments and preclude diagnosis before three years of age. The authors have found elevated levels of a binding protein in the umbilical cord plasma of patients with autism spectrum disorder relative to control patients. This protein serves as a biomarker for autism spectrum disorder which is detectable at birth. The authors have also identified genetic polymo...

Imaging method for early detection of autism in children

2378 — Current autism diagnosis methods are subjective processes typically based on behavioral observations taken at relatively late stages in a child’s development. This is largely due to a general definition of autism that comprises a broad range of symptoms, many of which are detected through assessments of a child’s speech and social skills. A method by which autism could be objectively detected at an early stage of life would facilitate earlier, more effective, treatment regimes. Th...

Freshly Frozen Tissue/Cell Microarrays that Retain Native Protein Integrity

1995 — Freshly frozen tissue / cell microarrays are useful for many biological applications, but generating them is time-consuming, inconvenient, and failure-prone. Generating a freshly frozen tissue or cell microarray involves freezing a block of embedding material, making holes in the block, and inserting a frozen tissue sample or optionally frozen or thawed cell sample into the holes. The procedure needs to be completed at temperatures below 0°C, so making holes in the receiving block or inserti...

Gene to Identify Wnt Signaling Pathway

730 — The Wnt signaling pathway is a complex network of proteins that plays a role in cancer, embryogenesis, adult neurogenesis and axon guidance. Given its relevance, the Wnt signaling pathway has been under intensive research. There is an ever-growing need for tools to quantify, localize and alter the cellular concentrations of Wnt-pathway molecules to serve as research tools and future therapeutics. and Zeng Li Available for Licensing and Sponsored Research Support

A new method to diagnose and mechanism to treat hormone-resistant prostate cancer

1727 — The discovery of the expression of a novel protocadherin, protocadherin-PC (PCDH-PC), which promotes malignant behavior and hormone resistance of prostate cancer cells by acting through the Wnt signaling pathway, has potential for affecting future cancer treatments and diagnostic tools. This technology represents a method for treating hormone resistant prostate cancer, as PCDH-PC activity can be reduced by utilizing an inhibitory siRNA directed against PCDH-PC. Furthermore, by assaying P...

Transgenic mouse for impaired expression of endogenous ZDHHC8 as Marker for Schizophrenia

1806 — Microdeletions in chromosome region 22q11 are associated, with relatively high frequency, with severe mental illness. Whereas a person in the general population has a risk of about 1% of developing schizophrenia, that risk may be 25-30 times higher in persons having a deletion in the 22q11 region. It therefore seems likely that the 22q11 region harbors genes that, alone or in combination, are causally implicated in schizophrenia. An emerging “"genetic”“ picture is that the 22q11 micro...

PicoRNAVirus for Diagnosis of Respiratory Tract Infections

2014 — Respiratory tract infections may result in a wide spectrum of disease that ranges from minor discomfort to exacerbations of asthma and COPD/emphysema to acute fatal respiratory failure. During an investigation of Influenza-like illness (ILI) using methods that enable molecular detection and discovery of both cultivatable and non-cultivatable microbes, we discovered a novel picornavirus that was subsequently classified by the International Committee for Taxonomy of Viruses as the prototyp...

Prostate Cancer Diagnostic, Prognostic and Therapeutic Tool using RAD9 Gene

2081 — Prostate cancer is the second most prevalent cancer type in American men and is now the second leading cause of cancer death within this group. Currently, there are a number of treatment options available, including surgery, radiation, chemotherapy, hormone therapy, and alternative approaches. Selecting one of these options often hinges on a number of factors including age, overall health, cancer grade, tumor localization/metastasis, and potential side effects. A cure for prostate cancer...

Discovery of a novel microRNA in normal and tumor-related Human B cells

2227 — There is evidence that structural or functional alterations of microRNAs are associated with tumorgenesis. This technology represents a way to identify B cell malignancies and provides a method to treat a given cancer by restoring the level of microRNA expression associated with that cancer to normal. The discovery of a microRNA that is differentially expressed during normal B cell differentiation and malignant transformation has potential to transform future B cell lymphoma diagnostics ...

Defects that Contribute to the Pathogenesis of Parkinson's Disease

2469 — Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. A small proportion of cases can be connected to genetic factors. However, in most cases, the complete molecular pathway explaining its pathogenesis is unknown. Some drugs are available to patients, but these were developed for cancer or infectious diseases, not PD. Before effective drugs and treatments specifically for PD can be developed, an understanding of the molecular basis of the disease must be found. T...

Parkinson's Disease Diagnosis through Transcriptome Wiring Analysis

2837 — Although whole transcriptome gene analysis has identified specific RNA transcripts differentially expressed between brain tissue in patients afflicted with Parkinson’s disease (PD) and healthy subjects, it is unclear to what extent these genetic differences are directly linked to the pathogenesis of PD. Moreover, differential expression analysis may not identify certain regulators integral to the disease that are not differentially expressed. The technology is a transcriptome anal...

Cervical Cancer Gene Markers for Targeted Therapy

2847 — Current treatment modalities for invasive cervical cancer result in largely unpredictable patient response. As a result, there is a pressing need for rational design of predictive biomarkers that can better guide treatment strategies in order to provide safer and more efficacious therapy. Recent advances in genomic and proteomic technologies have shown great promise in identifying biomarkers to enable more advanced diagnosis and allow for personalized therapy to improve clinical outcomes...

Cat Virus, Picornavirus Disease Diagnosis andTreatment

2939 — When animals are brought into veterinary clinics with disease symptoms, it is important to obtain accurate diagnoses in order to provide effective treatments. In particular, cats and dogs can suffer from a similar array of diseases as humans, including bacterial and viral infections. For cats, a family of viruses known as picornaviruses (caliciviruses) can cause serious respiratory disease. Diagnosis of this type of viral infection can be difficult since symptoms may be similar to other ...

Renal Cell Carcinoma Diagnostic

699 — The majority of kidney cancer deaths are caused by renal cell carcinoma (RCC). If RCC tumors are detected while still confined to the kidney, radical nephrectomy results in excellent long term survival. Unfortunately, symptoms of disease rarely occur prior to metastatic spread. Once RCC has metastasized, survival rates are less than 10% at five years. Until now, no suitable diagnostic marker existed for RCC detection, staging or for monitoring the effect of therapy. This invention provid...

MEMS-based Calorimetry for Biomolecular Characterization

m11-060 — In differential scanning calorimetry, a sample and a reference material are subjected to identical temperature variations at a prespecified rate within a range of interest. The thermally induced activity of the sample material, either exothermic or endothermic, will cause a difference in the thermal power between the sample and reference materials. This differential power is measured and used to compute the thermodynamic properties of the biomolecules. This technology is a MEMS-based (microe...

High Throughput Solid Phase Assay for Acetylcholinesterase (AChE) Activity

cu12029 — Acetylcholinesterase (AChE) is an enzyme responsible for the degradation of the neurotransmitter acetylcholine and has an important role in several diseases. Diseases such as Alzheimer’s and glaucoma are thought to be caused by reduced synthesis of acetylcholine and one therapy for such diseases is the use of an AChE inhibitor (AChEI). In order to administer such a treatment, one must first assess the level of AChE in the body and how modifications to the enzyme change its activity. For ...

Cancer Detection with Mutant-Enriched DNA Sequencing for Small Tumor PIK3CA Mutations

2153 — Altered regulation of the phosphatidylinositol 3-kinase (PI3K) signaling pathway has been associated with cancer development. Somatic mutation of one PI3K signaling component, PIK3CA (phosphatidylinositol 3-kinase, catalytic subunit p110a), has been identified in many tumor types including early lesions of breast cancer carcinoma, hepatocellular carcinoma, and gastric carcinoma, as well as head and neck squamous cell carcinoma (HNSCC). Given the involvement of PIK3CA in many aspects of t...

Early Detection of Liver Cancer by Methylated Tumor DNA in Blood

2218 — Hepatocellular carcinoma (HCC) is one of the most common and serious human cancers; nearly 500,000 patients are diagnosed annually. A lack of effective therapeutics and advanced stage diagnosis cause most patients to die with in a year of diagnosis. While HCC is highest in East Asia and Sub-Saharan Africa, it is also increasing in US. Current screening tests to detect early stage HCC use a combination of alpha-fetoprotein (AFP) analysis and ultrasound. However, though screening of early ...

Gab2 Gene Therapeutic Target for Melanoma

2344 — Melanoma is the fifth most common cancer in the US. If diagnosed in the early stages, melanoma can be treated with surgery; however metastatic disease has a poor prognosis with a median survival of 6-9 months. There is no therapy for thicker or metastatic melanomas proven to have a significant impact on survival. Therefore, there is an urgent need to identify novel therapeutic targets and develop new treatment strategies for this disease. This invention is the identification of a ...

"Chronic Obstructive Pulmonary Disease detection method "

2694 — Chronic Obstructive Pulmonary Disease (COPD) is a serious lung disease that includes chronic bronchitis, emphysema, or both. COPD is the fourth leading cause of death in the U.S, at an estimated 120,000 deaths/year. There is no known cure for COPD, as there is no way to reverse the damage to the airways and lungs. Currently, diagnostic markers for COPD are mostly limited to non-specific inflammatory proteins such as C-reactive protein and interleukins. More specific diagnostic markers co...

Saliva test detects periodontal disease

625 — The invention is a kit to allow in-office or at-home testing for periodontal disease in non-stimulated saliva. The test can be performed by several methods. One test utilizes substrates for b-glucuronidase that are added directly to the collected saliva. These substrates are then acted upon to result in products which are fluorescent and these levels can be compared to the standards to assess the severity of the disease. A second test utilizes substrates that, when acted upon, generate s...

Melanoma Differentiation Associated Gene

672 — Malignant melanoma is a serious type of skin cancer, due to uncontrolled growth of pigment cells. About 48,000 melanoma related deaths occur worldwide per year. Despite many years of intensive clinical research, the sole effective cure is surgical resection of the primary tumor before it achieves a thickness greater than 1mm. This technology exploited the defective differentiation process in melanoma cancer cells, constructed cDNA libraries from undifferentiated, actively prolifer...

Sodium Magnetic Resonance Imaging for Tumor Diagnosis, Treatment

810 — The ability to assess the chemotherapeutic efficacy against a tumor at an early stage has enormous utility. However, in vitro cytotoxicity assays are limited by the difficulty in obtaining fresh tumor tissue and culturing human cells in explant. In vivo assessment of chemotherapeutic efficacy is limited by the length of time required for a change in size in a measurable soft tissue lesion to occur, which can sometimes be weeks. In addition, some cancers metastasize predominantly in bone,...

Surface Plasmon Resonance (SPF) Biosensor for Measuring Anti-Glycolipid Antibody Levels in Neuropathy

1124 — This technology shows that PAK5, a novel target of the Rho GTPases Cdc42 and Rac, triggers filopodia formation and neurite outgrowth in neuronal cell lines, a finding that holds great promise for future drug development. It provides new nucleic acids encoding human PAK5-related proteins as well as the encoded proteins. Additionally, methods to regulate various cellular processes using the instant nucleic acids and proteins are described. Norman Latov M.D. Neurological Disease ...

Polypeptides for transplant rejection detecting and treatment

1587 — The invention includes methods for detecting and treating allograft transplant rejection, as well as for modulating the T cell immune response. A specialized subset of T suppressor (Ts) cells with the phenotype CD8+ CD28- FoxP3+ inhibits the activation of CD4+ T helper (Th) cells in an antigen-specific manner. It does so by interacting directly with specific antigen-presenting cells (APCs) such as dendritic cells and monocytes, as well as with endothelial cells (ECs), then inducing the u...