Columbia University

Technology Ventures

New Gene Discovery Through Comparisons of Networks of Known Genes and Proteins

Technology #816

Identifying Novel Genes, Simulation, Hypothesis Testing for Gene of Interest:

The method comprises generating one/more specialized databases containing information on gene/protein structure, function and/or regulatory interactions and searching the databases for homology/for a particular motif and thereby identifying a putative novel gene of interest. A method for identifying the affect of a gene knockout on a regulatory pathway and for identifying a novel nucleic acid molecule encoding a protein of interest is also provided.

Gene Databases Allow for Discovery of Novel Genes: The method provides for the generation of specialized databases containing information on gene/protein structure, function and regulatory interactions based on the retrieval of such information from research articles and databases, and computer representation of such information in a manner that allows efficient access to the extracted information. This allows for the identification of genes that contribute to the phenotype of a specific disease associated with a particular biological system under analysis.