Columbia University

Technology Ventures

Tissue regeneration by recruiting stem and progenitor cells using PDGF

Technology #2819

Lead Inventor: Jeremy J. Mao, DDS, PhD

Use of platelet-derived growth factors (PDGF) to induce migration of stem/progenitor cells

Populations of stem/progenitor cells are undifferentiated and with appropriate signals, can differentiate into specialized cells like adipocytes and endothelial-like cells and regenerate adipose and blood vessels, respectively. Stem/progenitor cell transplant may be a method to treat tissue or organ defects. A scaffold comprising PDGF induces stem/progenitor cells to migrate towards the source of PDGF. This allows for a population of stem/progenitor cells to be recruited to a site in need of tissue regeneration. The use of endogenous cells avoids the need for allotransplant.

Use of autologous stem/progenitor cells for tissue regeneration decreases chances of host-rejection and issues with regulatory affairs

Tissue regeneration is often needed to treat diseases and injuries. Stem/progenitor cell assisted tissue regeneration is gaining interest, but complications like host-rejection can arise when stem/progenitor cells are isolated and transplanted from another patient. Using the patient to derive their own stem cells reduces the chances of transplant rejection. This method also reduces the chances of pathogen-transmission and mishandling of the cell transplant, decreasing the costs and resources associated with complying with regulatory bodies.

Applications:
– Use of PDGF to recruit stem/progenitor cells for treatment of tissue degeneration, like alveolar bone loss after tooth loss
– Use of PDGF to recruit stem/progenitor cells for regeneration of damaged tissue after injury

Advantages:
– PDGF (a protein) recruits stem/progenitor cells
– Improves safety by decreasing chances of transplant-associated disease transmission
– Improves effectiveness of treatment by decreasing chances of host-rejection of cell-transplant
– Improves efficiency since stem/progenitor cells do not have to be packaged or stored in between donor and recipient
– Stem/progenitor cells can be used to generate different types of tissues

Patent information: WO/2012/045086 ~ see link below.

Licensing Status: Available for licensing and sponsored research support