Columbia University

Technology Ventures

Discovery of novel canine viral species creates opportunity for vaccine development

Technology #2801

Lead Inventor: Walter Ian Lipkin M.D.

Tech Ventures Reference: IR 2801; IR 2805; IR CU12262.

New canine viral species, each unique and displaying novel genetic makeup unlike existing viruses.

The Canine Bocavirus (CBoV) and Canine Kobuvirus type 1 (CKoV) belong to the parvovirus and picornavirus families respectively. Both viruses were discovered in canines with respiratory and gastrointestinal problems. Phylogenetic analysis on genomic sequences and protein alignments confirms the classification and novelty of CBoV and CPKoV. Since both these viruses are highly divergent in respect to existing viral species within their family, no effective ways to treat against them directly are currently available.

The Canine Circovirus genotype-1 (CaCV-1) belongs to the circovirus family. The classification of this new species provides the first direct evidence of an evolutionary relationship between two distinct virus families that includes genetically diverse viruses with single-stranded DNA circular genomes.

Classification of previously unknown viral species furthers efforts towards the prevention and treatment of infections.

Canine parvovirus is the most common infectious disorder in the US for canines and is one of the recommended core vaccines by the American Veterinary Medical Association. However, current vaccines do not protect against all parvoviruses. Thus, there is an ongoing need to identify additional parvoviruses, develop diagnostics to detect viral infections, and develop therapeutics and/or vaccines against infections caused by these viruses. Additionally identifying novel viruses that infect companion animals is critical as many human infectious diseases come from domesticated animals.

This technology can open avenues of research to study the pathogenesis, diagnostics, therapeutics and immunotherapies of these infectious disorders. Characterization of the mechanisms behind these viral infections could also potentially lead to the development of vaccines.

Applications: • Development of diagnostic methods to detect infection • Development of new vaccines against CBoV, CKoV, and CaCV-1 • Elucidate mechanisms of parvovirus, picornavirus, and circovirus viral pathogenesis • Enables virology community to investigate new viral infections • Allows development of molecular reagents to identify more novel virus species

Advantages: • More effective prevention of viral infections • Enhanced treatment options for viral infections • More complete understanding of viral species

Patent information: See links below.

Licensing Status: Available for licensing and sponsored research support

Related Publications: • A. Kapoor, P. Simmonds, E.J. Dubovi, N. Qaisar, J.A. Henriquez, J. Medina, S. Shields, W.I. Lipkin. Characterization of a canine homolog of human aichivirus. Journal of Virology, Vol. 85, Issue 21, Nov. 2011, pp. 11520-11525.

• A. Kapoor, N. Mehta, E.J. Dubovi, P. Simmonds, L. Govindasamy, J.L. Medina, C. Street, S. Shields, W.I. Lipkin. Characterization of novel canine bocaviruses and their association with respiratory disease. Journal of General Virology, Vol. 93, Issue 2, Feb. 2012, pp. 341-346.

• W.I. Lipkin et al. Complete Genome Sequence of the First Canine Circovirus. Journal of Virology, Vol. 86, Issue 12, June 2012. In Press.

Other Links: WIPO – patent - WO/2012/030786 WIPO – patent - WO/2012/030778