Columbia University

Technology Ventures

Hybrid soft tissue augmentation from stem cells and biomaterials

Technology #2194

Consumers and medical professionals continue to seek better solutions for soft tissue augmentation and reconstruction that address the maintenance of soft tissue shape, dimension, and biocompatibility. This technology is a method for generating hybrid breast implants consisting of artificial implant materials surrounded by fat tissue generated from stem cells. These implants circumvent numerous undesirable side effects of traditional silicone or saline based materials. The artificial breast material is surrounded by fatty tissue from stem cells, masking the foreign implant from the host and improving incorporation and long-term survival of the implant. This method for generating hybrid breast implants may also be used for the reconstruction of other soft tissues.

Hybrid implants retain the bio-integrative properties of adipose tissue while minimizing the volume of live tissue necessary for fabrication

The hybrid soft tissue implants described in this technology avoid many of the negative side effects associated with traditional silicone or saline based materials. The use of a fatty tissue coat improves host incorporation, whereas the synthetic core reduces the possibility of unwanted reduction of the implant’s volume. In addition, this method requires minimal donor tissue, only using a small amount of stem cell material, reducing donor site morbidity. This technology also improves the long-term survival of the implants and produces a more natural appearance of the reconstructed breast. The hybrid tissue has been tested extensively in the laboratory.

Lead Inventor:

Jeremy J. Mao, Ph.D.


  • Implants for use in breast reconstruction following lumpectomy or mastectomy in breast cancer patients, or other patients suffering a significant loss of breast tissue
  • Implants for reconstruction of other soft tissues
  • Implants for cosmetic breast augmentation procedures


  • Avoids side effects associated with traditional silicone or saline based implant materials
  • Improved host incorporation with minimal donor site morbidity
  • Requires minimal donor tissue
  • Improved long-term survival of the implant
  • Facilitates integration with host tissue
  • Implants result in a more natural reconstructed breast

Patent Information:

Patent Issued (US 9,199,002)

Tech Ventures Reference: IR 2194

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