Columbia University

Technology Ventures

Mullerian Inhibiting Substance (MIS) Analogs for Endometriosis Treatment

Technology #2135

“Lead Inventor: Drew Tortoriello, MD.

Endometriosis Treatments Slow Acting and Include Side Effects While surgical and medical treatments are available to treat endometriosis, none of the available options provides optimal long-term solution. Specifically, hormonal therapy is slow at providing substantial pain relief and is associated with side effects that include androgenic effects or menopausal symptoms. Additional or alternative hormonal therapies are needed to inhibit abnormal uterine tissue growth and the resulting pelvic pain that in order to optimize patient care.

Mullerian Inhibiting Substance (MIS) Analogs Optimize Treatment for Endometriosis and Cervical Cancer The present invention comprises of recombinant analogs of Mullerian Inhibiting Substance (MIS) that comprise one or more non-naturally occurring N-glycosylation sites, protease cleavage sites or epitope tags. The analogs inhibit proliferation of tissues that are derived from the Mullerian duct, and are therefore candidate drugs to treat disorders that stem from unregulated Mullerian-duct derived tissue growth, including endometriosis and uterine, ovarian and cervical cancers.

Applications:
• Therapy for endometriosis.
• Treatment for cervical, ovarian and/or uterine cancer.
• Treatment for adenomyosis and uterine fibroids.
• Induction of apoptosis in cultured cells of Mullerian duct origin.

Advantages:
• MIS analogs only inhibit proliferation of tissue of Mullerian duct origin and, hence, side effects may be limited in comparison with other hormonal therapies.
• May be administered orally, intravenously, transdermally or locally.


Patent Status: Patent Pending. WO/2010/017290 A1 ~ see link below.

Licensing Status: Available for Licensing and Sponsored Research Support.

Publications: Wang J, Dicken C, Lustbader JW, Tortoriello DV, Evidence for a Müllerian-inhibiting substance autocrine/paracrine system in adult human endometrium. Fertil Steril. 2009 Apr;91(4):1195-203. Epub 2008 Mar 7