Columbia University

Technology Ventures

PicoRNAVirus for Diagnosis of Respiratory Tract Infections

Technology #2014

“Lead Inventor: Ian Lipkin

Respiratory Tract Infection Diagnosed with Picornaviruses (Rhinovirus C) Respiratory tract infections may result in a wide spectrum of disease that ranges from minor discomfort to exacerbations of asthma and COPD/emphysema to acute fatal respiratory failure. During an investigation of Influenza-like illness (ILI) using methods that enable molecular detection and discovery of both cultivatable and non-cultivatable microbes, we discovered a novel picornavirus that was subsequently classified by the International Committee for Taxonomy of Viruses as the prototype of a new clade of picornaviruses (rhinovirus C) and determined to be globally distributed in association with significant pulmonary disease.

Picornaviruses (Rhinovirus C) for Virus Detection and Therapeutic Agent This technology is directed to address a group of picornaviruses (rhinovirus C) associated with respiratory infection. This invention encompasses: • Isolated nucleic acid sequences • Peptides associated with isolated nucleic acid sequences • Interfering RNA (iRNA) directed against relevant sequences • Antibodies against relevant peptides This technology can be used to detect the presence or absence of the virus in a subject. The iRNA described in this invention could be used as therapeutic agents to lower viral titers in patients. This invention also describes methods for inducing an immune response against the virus in a subject.

Applications: • Differential diagnosis of respiratory tract infection and detection of the virus • Vaccines to prevent infection and disease due to the virus • Therapeutic agents to prevent or ameliorate disease due to the virus

Advantages: • Detects the novel virus • Offers rapid and specific detection of the virus • Treatment in the form of a specific iRNA can be tailored to the diagnosis • Offers a method of vaccination such that a specific immune response against the virus can be induced

Opportunities: • Assay for amplification and detection of virus • Assay for detection of an immune response against the virus • Development of vaccination against the virus • Development of iRNA based therapeutic agent for reducing the vira titer

Patent Status: International Patent Application (WO 2008/016594)

Licensing Status: Available for Licensing and Sponsored Research Support

Publications: - J Infect Dis. 2007 Dec 15;196(12):1754-60. A recently identified rhinovirus genotype is associated with severe respiratory-tract infection in children in Germany. - J Infect Dis. 2006 Nov 15;194(10):1398-402. Epub 2006 Oct 6. MassTag polymerase-chain-reaction detection of respiratory pathogens, including a new rhinovirus genotype, that caused influenza-like illness in New York State during 2004-2005.