Available Technologies
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Polycrystalline Thin-Film Silicon for Solar Cells through Flash Lamp Annealing
m08-067 — This technology provides a method for creating polycrystalline thin-film silicon for use in solar cells. In contrast to current methods that use expensive lasers, this technology uses low-cost flash lamps to crystallize silicon films on large areas of glass or metal substrate with low intragrain defect density. This method could offer higher levels of stability and efficiency than current polycrystalline thin-film silicon fabrication methods, and at a lower cost of production. The ...
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m11-120 — This suite of algorithms and software, named PDFgetX3, converts X-ray diffraction (XRD) data into total scattering pair distribution functions by numerically transforming XRD data from frequency space into position space. This conversion allows characterization of drugs and industrial materials in their amorphous and nanocrystalline state. Currently, the great majority of drugs are produced in a crystalline state. This keeps the drugs stable but can limit other desirable properties like...
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1985 — This photo-activated glycan array could be used to develop immunoassays to detect pathogens and identify infectious diseases. The array targets the complex sugars pathogens carry on their surfaces - carbohydrates that are specific to each pathogen and less mutable than the than resident proteins traditionally targeted in disease identification and pathogen detection. Using the array, researchers have identified the immunogenic sugar moieties of anthrax () spores, enabling the rapid...
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2958 — This cell block preparation device biopsy system, called XCellent, is a disposable filtration system for fine needle aspirations (FNAs), fluids, and small biopsies that maximizes cell collection from minute tissue samples. XCellent can be used in cytology laboratories that process cell blocks or small biopsies, by clinicians who perform FNAs, and by research laboratories that seek to isolate cells from a liquid component. In fine-needle aspiration, the entire FNA sample (<1ml) consist...
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1857 — This technology minimizes bronchospasm (or bronchoconstriction) and the contraction of muscles in the airway due to irritation, such as during endotracheal intubation. Asthma and Chronic Obstructive Pulmonary Disease (COPD) sufferers are particularly at risk while under anesthesia during such a procedure, due to a neural reflex that causes airway smooth muscle to contract and constrict the airway. According to the Centers for Disease Control (CDC), the number of people with asthma ...
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m11-072 — This gas-to-liquid (GTL) fuel conversion method efficiently converts natural gas into liquid fuels by generating a synthetic gas, or syngas, that can be further reformed into gasoline, diesel and jet fuel via existing industrial methods and infrastructure. This technology uses a novel two-step reaction mechanism and small-scale reactors that can produce liquid fuel with current small-scale Fischer-Tropsch methods, or as an alternative to that approach. This technology prodices more liqu...
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2793 — This minimally-invasive obesity treatment is an injection that inhibits immune response in a specific population of immune cells, triggering fat loss. Obesity provokes an inflammatory immune response, causing insulin resistance in adipose (i.e. fat) tissue. In addition to causing fat retention, this can lead to diabetes and other metabolic disorders. Researchers at Columbia decreased a specific population of immune cells with an injection. This prevented inflammation and subsequen...
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2419 — This hair-loss gene technology represents a non-surgical hair-loss treatment and a potential drug target for preventing further hair loss. The discovery of the APCDD1 gene, which causes hair loss, has potential for future male-pattern baldness treatments, and for regulating male and female hair growth, density of hair, and hair graying. Hair loss affects millions of people worldwide. Hair loss can be an emotionally devastating skin disease, as measured by impact on quality of life. Two...
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Video Editing, Content-Based Visual Search for Compressed Digital Video Files
ms94-07-17b — This visual search and video editing software allows users to perform content-based searching, video editing and indexing, and to add video special effects to digital videos in the compressed video file. Digital video is a huge part of the ongoing multimedia revolution. Forty-eight hours of video are uploaded every minute to , nearly eight years of video content per day, according to statistics from the online video server. To conserve bandwidth, the vast majority of those videos a...
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Natural Skin and Surface Disinfectant from Botanicals, for Use in Antimicrobial Soaps and Products
2371 — This natural disinfectant composition is composed of natural essential oils, fruit acids, and alcohols that work together to kill a broad spectrum of bacteria. The botanicals used in this skin disinfectant have emollient and moisturizing properties and are very mild to the skin. The botanicals can be used as non-irritiating, non-toxic skin and surface disinfectants, such as in antimicrobial soaps, creams, lotions, cosmetic products, and wound dressings in home or clinical settings. ...
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CUMC Radiology Imaging Lab Available Technologies
2906 — Listed below are technologies available for licensing from the Tumor segmentation, which detects tumor boundaries, is very important for analysis of medical images such as computed tomography (CT) and magnetic resonance (MR) images. While medical imaging methods are greatly advanced by the development of modern electronic technology, manual tumor segmentation is not able to satisfy the increasing need for medical image processing due to the low speed and high cost. Computer-aided de...
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cu12290 — Hydraulic fracturing, also called fracking, is a technique used in the oil and gas industry to break apart rock in wells for enhanced extraction of hydrocarbon fuels that are trapped in the rock pore space. Unlike conventional hydraulic fracturing, which has raised environmental concerns due to the fluids used for injection, this technology is based on reaction driven cracking utilizing non-toxic, readily available fluids. Reaction driven cracking uses precipitation reactions as opposed to h...
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m05-055 — This technology improves upon existing methods via laser oxide removal of the thin-film, followed immediately by immersion plating/etching of the exposed surface. Reducing the process to one or two steps greatly improves the efficiency and uniformity of plating/etching materials naturally coated by thin films. This technology could also contribute to efficient fabrication of new forms of lithium ion batteries. Moreover, plating metal electrodes could limit the harmful effects of c...
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Gene Transduction Therapy in Neurodegenerative Disorders
cu12241 — The p70S6K gene has been discovered to induce axonal growth when in a constitutively active state. In order to simulate Parkinson’s disease in a mouse model, the Substantia Nigra (SN) was lesioned. Constitutively active p70S6K was introduced into the SN utilizing viral vector induction three weeks after lesioning. These mice showed significant axonal regeneration in this area 12 weeks following introduction of the constitutively active p70S6k gene. Available for licensi...
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Laser Welding of Dissimilar Metals without Filler Material
m11-074 — This technology enables the joining of dissimilar metals, such as shape memory alloys and stainless steel, without using filler materials. A laser precisely irradiates the interface between two metals, bonding them with high joint strength. The laser is shut off immediately once the metals melt, in order to prevent the interface from mixing and forming a brittle intermetallic region. The applications of this cost-effective technology span a wide range of industries such as the automotive, ae...
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Gait analysis using reflective light
m10-027 — Total Internal Reflection describes a condition present in certain materials when light enters one material from another material with a higher refractive index, at an angle of incidence greater than the critical angle. Frustrated total internal reflection (FTIR) occurs when a third medium with a higher refractive index than the second medium is placed within less than several wavelengths distance from the interface between the first medium and the second medium. Small bursts of light transm...
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Free-Standing Graphene Films as Calibration Standards for Force Measurements at the Nanoscale
m09-013 — This technology couples suspended graphene sheets with a force transducer, making calibration standards for nanoscale forces. Graphene has a known specific initial tension when suspended above a circular well of a known diameter. When measured with AFM, this yields a well-defined force-versus-displacement curve. Since the number of layers in the graphene membrane can be changed to alter its rigidity, these devices can provide ideal force calibration standards covering a broad stiffness range...
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Software Controlled Optical Lithography for for Electronic Device Production
m07-063 — Lithography is used extensively in the fabrication of electronic devices. Cutting edge projection lithography uses ultraviolet light projected through a series of masks to define the features of an electronic microchip. However, with the increasing complexity of microchips, these masks are becoming increasingly expensive and must be re-manufactured for every design change. Other lithography techniques include electron beam lithography, which is a serial write process where the electron b...
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Enhanced voIP Emergency Services Prototype for Emergency Calling (E911)
m07-045 — Invention: Composition and methods for de novo and in vivo synthesis of adipose tissue implants in predefined and sustained shape and dimension. Unmet Need: Consumers and medical professionals continue to seek better solutions for soft tissue augmentation and reconstruction that address maintenance of soft tissue shape and dimension and biocompatability. A variety of technologies are available for soft tissue augmentation, repair and reconstruction at varying scales. These include aut...
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Copper Oxide Nanoparticle System for Catalytic Converters
m06-079 — Carbon monoxide is a colorless, tasteless and odorless gas that can cause serious cardiovascular and neurobehavioral effects at low concentrations and death at high concentrations. It comes from a variety of sources such as automobile exhaust, cigarettes, furnaces, heaters, industrial manufacturing units etc. One approach to make this gas harmless is to convert it into carbon dioxide through catalytic oxidation. Such an approach is currently incorporated in majority of carbon monoxide pu...
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Micro- and Nano-photonics for sensing displacement, strain, vibrational, and thermal sensing
m06-025 — Effective sensors in industrial manufacturing processes are necessary in order to monitor proper conditions necessary for quality assurance. However, some manufacturing processing cycles require hostile conditions, such as elevated temperatures, large strains, and/or active electromagnetic interferences which can interfere with proper function of electronic sensors. The technology details uses of integrated microphotonic devices, e.g., microring or photonic crystal resonators, for...
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m06-003 — Inorganic nanocrystals have numerous applications in diverse fields such as catalyst production, ultramodern electronic and electroptical devices, super-magnets, photographic suspensions and are a benchmark model for nanotechnology given the tunability of their optical, magnetic, and mechanical properties. This technology is a wet chemistry procedure for the manufacture of discrete, monodisperse, stable, and size uniform nanocrystals using thermal decomposition of metal acetates. The nan...
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Extraction of Carbon Dioxide from Air
m05-026 — A method and device for extracting carbon dioxide from air using wet scrubbing and returning the carbon dioxide to a gaseous form after several chemical transformations are disclosed. Air containing carbon dioxide is exposed to sodium hydroxide solution to form sodium carbonate, which is then causticized using calcium hydroxide. Carbonate ion is transferred from sodium to calcium cation, to form calcium carbonate precipitate. The precipitate is thermally decomposed at a temperature above...
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Diagnose and regulate glioblastoma tumor cells through transcription factor ATF5 activity
1649 — Transcription factor ATF5 is a protein involved in the growth and persistence of glioblastoma tumor cells. This technology provides both a method to diagnose and treat tumors through modulation of ATF5 activity. Given that ATF5 is implicated in several types of cancer, the efficacy of this technology also expands to tumors in the breasts, kidney, prostate, and colon and has shown tumor specific effectiveness, leaving healthy cells intact. By regulating ATF5 expression, it is possible to mini...
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Controlled Nanoparticle Thin-Film Deposition for Next-Generation Electronics
m02-027 — Uniform nanoparticle film deposition methods will be critical for next-generation electronics applications. While nanoparticles' quantum and electronic properties hold great promise for powerful, compact electronic devices, the scale-up of nanoparticle thin films has been hindered by deposition difficulties. Existing techniques produce rough films that are susceptible to dissolution during fabrication. This technology provides a scalable, cost-competitive method for controlled nanoparticle d...
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Eco-Friendly Removal of Scratches from Glass as Scratchitti Vandalism Solution
m00-071 — Unsightly scratches on glass surfaces, whether from graffiti or accidents, are often difficult and expensive to repair. This technology provides a heat treatment method and apparatus to repair cracks and scratches while on glass surfaces while maintaining their structural integrity. The heating apparatus is affixed onto the surface of the glass. A high heat source passes across the scratches at a controlled speed and distance from the surface. This induces melting (or softening) of a thin la...
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Cell Lines from Adult Human Ventricular Cardiomyocytes for Cardiac Research
823 — Current cardiac research is restricted by very limited cell sources, as human primary cardiomyocytes have a finite life-span in culture before becoming terminally differentiated. Attempts to immortalize ventricular cardiomyocytes in order to establish a proliferating human cardiomyocyte cell line for research have not been successful. This technology established a ventricular cardiomyocyte cell line from human primary cardiomyocytes by a novel mitochondrial function-based immortalizat...
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Stress analysis of materials using a defect-free four-node finite element technique
ms96-05-15 — Lead Inventor: Tech Ventures Reference: IR MS96/05/15 Current finite-element techniques for stress analysis use triangles and/or quadrilateral shaped finite elements. These shapes introduce error when analyzing bending bodies and add artificial “stiffening,” or additional zero-energy modes other than rigid-body responses. This technology is an improved computer aided stress-analysis technique for two-dimensional bodies of uniform thickness. It uses quadrilaterals, free of these modeling...
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Carbon dioxide emissions capture and mitigation
m04-022 — Methods and cryogenic system for capturing, sequestering, storing, disposing of, or entraining carbon dioxide (C02) in the air environment and mitigation of carbon dioxide emissions are described. Magnesium bearing silicate is dissolved in an aqueous acid. The pH of the solution is increased to produce dissolved magnesium component. The resulting solution is neutralized by adding ammonia solution. The precipitated magnesium component is carbonated to sequester carbon dioxide from the air...
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Boosting Algorithm for Machine Learning and Pattern Recognition
cu12127 — In machine learning, classification algorithms use classification functions to search for patterns and/or images within data. The better the classification functions, the more accurately the algorithm can identify patterns. Boosting is a technique whereby poor classification functions (“weak learners”) are combined to form a single function with a much higher accuracy (a “strong learner”). This is typically done by determining how accurate a number of learners are against a series of exampl...
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Hybrid Transfection Method for Cells, Genetic Material
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Discovery of a Non-Primate Hepacivirus Related to Hepatitis C Virus
2853 — This technology can be used in developing therapeutic agents and diagnostic tools for treating and detecting the Hepatitis C Virus (HCV) and its homologs in humans and animals, including canines. A previously unknown virus named canine hepacivirus (CHV) has been shown to be the most genetically similar animal virus related to HCV. Initially isolated in dogs, several genetic variants of CHV have been shown to infect horses as well. An infectious clone for NPHV will pave the way for experi...
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Wireless magnetic resonance (MR) tracking of medical devices in the body
1438 — Magnetic resonance imaging (MRI) is frequently used to track the position of and guide devices that are inserted into the body as part of medical procedures and surgeries. However, existing technologies rely on active or passive tracking techniques that have significant drawbacks and offer poor results. Many of these technologies rely on subtle signal artifacts, offer poor signal to noise ratios, or require electrical wires to connect the inserted device to an external monitor. This technolo...
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cu12071 — Schizophrenia is a severe psychiatric disorder that affects almost 1% of the population. Despite its frequency, little is known about the biological causes of the disease or how the disease progresses. Columbia scientists have uncovered an association between Schizophrenia and a surplus of the amino acid proline, a condition known as hyperprolinemia. Because of a deficit of the catalytic enzyme responsible for the degradation of proline, proline dehyrdrogenase (PRODH), an excess of pr...
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Development of Sustainable, Ultra-Low Cost Construction Materials
cu13216 — Recycled concrete aggregate (RCA) is produced using an internal curing process. Unlike conventional curing which only wets the top layer of the concrete, internal curing wets the concrete throughout, providing a reservoir of water as moisture is lost due to evaporation. Concrete can also be reinforced with natural materials such as sisal fiber and bamboo, as opposed to traditional steel, to increase the strength of the RCA while minimizing weight. The use of natural, sustainable, fast-growin...
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cu12243 — Aluminum-coated glass wool effectively filters cellular biomass from oligotrophic waters. These columns are easy to use and provide highly efficient, high-throughput water filtration. Aluminum-coated glass wool filters capture particulates as small as 0.1μm through electrostatic interactions. Particulate acquisition continues, without impeding fluid flow, until all binding sites are filled. As the filter contains no carbon coatings or residues, it is particularly suitable for compound speci...
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Low-temperature energy conversion from CO2 and waste heat using a ceria-based nanoparticle catalyst
cu12075 — A ceria-based nanoparticle catalyst is designed for a waste-to-energy conversion system. The catalyst facilitates the reaction of CO2 and H2O to produce synthesis gas, a mixture of CO and H2 which can be combusted for electricity production or used as a feedstock to synthesize a wide range of organic chemicals and fuels. This process capitalizes on free and abundant waste heat, and even solar heat, to supply reaction energy. Waste CO2 is used as a CO precursor with non-potable water as a hyd...
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cu13148 — This technology is a health promotion software program targeting adolescent girls in public housing and their relationships with their mothers. The goals of this software are to increase physical activity, prevent drug abuse, and improve nutrition for high-risk adolescent girls. Additionally the program is designed to improve the mother-daughter relationships as it can be utilized in the home. Mothers and their daughters complete a 3-session program including session topics such as: healthy ...
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Cell culture technique to produce human and mouse prostate organoids
cu13124 — Prostate cancer is the leading cancer among men in the United States, with an annual incidence of over 144 per 100,000 men, and it is a heavily investigated disease. Most research currently being conducted on prostate cancer relies on the use of established, immortal cell lines to model the disease. However, these laboratory-based cell lines can differ from the actual prostate tissue in a human. Even with prostate tissue obtained via prostatectomy or cystoscopy, current methods fail to maint...
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Enhancing the antidepressant efficacy of SSRIs via simultaneous stimulation of histone expression
cu12070 — Coupling SSRIs with HDAC inhibitors can enhance the antidepressant efficacy of mood disorder treatments over SSRIs or HDAC Inhibitors alone, a new augmentation strategy for SSRI’s antidepressant treatment. Selective serotonin reuptake inhibitors (SSRIs) are the first line of treatment for depression. However, these drugs are far more effective at treating severe depression compared with mild or moderate depression. This technology demonstrates that the efficacy of SSRI treatment of mood d...
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Real-Time Diagnostic Assays for Cardiovascular Shock using Neuro-Humoral Factors
1875 — Tardy diagnosis of cardiovascular shock can be life-threatening resulting in a need for rapid and accurate assessment in order to deploy treatment. This technology assays neuro-humoral factors (NHF), hormones that regulate blood pressure, to detect early signs of shock in real-time. It consists of the preparation of capture agents, which bind to NHF for assay use and the possible configurations of the assay. With this NHF assay real-time diagnosis of cardiovascular shock and subsequent treat...
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cu12297 — Current microscopy techniques require large volumes of cells, of which only a small number are in the observable area (as low as 0.1% of the starting amount). This is especially challenging in the study of rare cell populations, where maximal recovery of cells to the observational area is critical. This technology is a custom designed cell culture well, which maximizes cell recovery to an observational area. The well is angled towards the bottom which leads to a small, flat, observational ar...
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cu12242 — Prostate cancer is the second leading cause of cancer in the United States, and its aggressive forms are attributed to have a mortality rate second to only lung cancer. Prostate cancer arises in the prostate gland and can metastasize to other parts of the body, but the differentiation stages that enable prostate cells to undergo transformation are inadequately understood. This is in part due to inaccurate early prognostic markers and limited research models of prostate tissue and its com...
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Sharp, high-resolution Magnetic Resonance Imaging (MRI) using novel coil decoupling method
cu12151 — Multi-element array of radio frequency coils are utilized in parallel to achieve improved image acquisition speeds and image resolution. While existing approaches suffer from inductive coupling between coils, this technology utilizes high impedance coils to decouple coils and eliminate mutual inductance. High impedance coils limit the flow of current thus inhibiting the inductance of voltage in one coil from the current flow in a neighboring coil. This reduction in inductance interferenc...
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Post Concussion Syndrome Treatment
2933 — Concussion symptoms related to post-concussion syndrome, once known as “shell shock,” can be effectively treated with this therapeutic approach. Post-concussion patients administered 4-amino pyridine, a chemical compound currently used against multiple sclerosis and other nervous system disorders, may find reprieve from a range of post-concussion symptoms. 4-amino pyridine is known to block voltage-gated potassium channels in neurons, speeding up the firing of action potentials. C...
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The use of TRPV3-directed compounds for prevention and treatment of non-melanoma skin cancers
cu13094 — Transient Receptor Potential Channel 3 (TRPV3) receptors are expressed in keratinocytes and influence cell proliferation and differentiation via a mechanism that regulate cytoplasmic calcium. This technology has identified TRPV3 as being dysregulated in human cutaneous Squamous Cell Carcinoma (cSCC). Furthermore, moderate TRPV3 activation with small molecule agonists has been found to arrest proliferation and reduce tumor size in human preclinical models. These findings suggest TRPV3 mod...
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cu12186 — Graphene, a single atom thick form of carbon, possesses a variety of useful electrical and optical properties that make it highly suitable for ultrafast, low power, chip-scale optoelectronic applications. In particular, the high nonlinear optical response of graphene enables it to be used to construct ultrafast photonic logic gates and memories, generate light pulses at low energies, and amplify optical signals. The current technology takes advantage of these capabilities via hybrid grap...
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m11-014 — Current technologies for robotically assisted surgery have limited deployment due to long setup times, prohibitively high equipment costs, and large physical footprints. They may also be limited to specific surgical sites due to rigid instrumentation. These barriers often make robotics impractical for the majority of minimally invasive procedures. There is a clear need to bridge the gap between minimally invasive procedures and advanced clinical robotics. This technology describes a nove...
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484 — Heregulin is a growth factor with multiple splice variants, each having different functions. One variant, called nARIA, plays a role in synapse formation. This establishes nARIA as a potential therapy for a multitude of neurological diseases such as Alzheimers, ALS, myasthenia gravis, and many others. Certain forms of cancer also exhibit improper over-expression of nARIA, indicating that it can serve as a diagnostic parameter. Furthermore, these forms of cancer may be treated by reducing...
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PCR assay detects mutant genes with 50 to 100-fold increase in sensitivity
cu12130 — Polymerase chain reaction (PCR) involves separation of double stranded DNA and sequential amplification of target genes in order to detect gene sequences. This technology encompasses two modifications to increase the sensitivity of PCR, via preferential replication of the target of interest. One method involves a primer which allows for amplified alleles to denature at lower temperatures while creating a thermostable endonuclease site in wild-type alleles that lack a native restriction s...
